Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 3858209..3859000 Replicon chromosome
Accession NZ_CP025892
Organism Escherichia coli strain 503025

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CXX03_RS19220 Protein ID WP_001717032.1
Coordinates 3858575..3859000 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CXX03_RS19215 Protein ID WP_001296928.1
Coordinates 3858209..3858544 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX03_RS19190 3854155..3854373 - 219 WP_001064742.1 AlpA family phage regulatory protein -
CXX03_RS19195 3854491..3855105 - 615 WP_000772911.1 inovirus Gp2 family protein -
CXX03_RS19200 3855698..3856651 + 954 WP_000290409.1 hypothetical protein -
CXX03_RS19205 3856888..3857706 + 819 WP_001296926.1 DUF945 domain-containing protein -
CXX03_RS19210 3857736..3858209 + 474 WP_001296921.1 DNA repair protein RadC -
CXX03_RS19215 3858209..3858544 + 336 WP_001296928.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXX03_RS19220 3858575..3859000 + 426 WP_001717032.1 TA system toxin CbtA family protein Toxin
CXX03_RS19225 3859021..3860212 + 1192 Protein_3694 AAA family ATPase -
CXX03_RS19230 3860197..3860418 + 222 WP_126125326.1 hypothetical protein -
CXX03_RS19235 3860415..3861146 + 732 WP_001216640.1 TIGR02646 family protein -
CXX03_RS19240 3861769..3862155 + 387 WP_001270938.1 DUF2441 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3844929..3861146 16217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16522.19 Da        Isoelectric Point: 10.2369

>T92337 WP_001717032.1 NZ_CP025892:3858575-3859000 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQILLARLLEQHYGLNLNDTPFNNEKVIQERIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDVLRARQATGLRIQCKNTNIISRMADSRHDKRLYQRTFKACKRCYYTKT

Download         Length: 426 bp

>T92337 NZ_CP025892:3858575-3859000 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAATATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACGCATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAGTTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATGTTTTACGGGCGCGACAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12565.57 Da        Isoelectric Point: 7.7245

>AT92337 WP_001296928.1 NZ_CP025892:3858209-3858544 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKHLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp

>AT92337 NZ_CP025892:3858209-3858544 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACATCTGGAGCTGAAACTGGCTGACGGTGAACTCTCTCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References