Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1584776..1585563 Replicon chromosome
Accession NZ_CP025892
Organism Escherichia coli strain 503025

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CXX03_RS07895 Protein ID WP_001716546.1
Coordinates 1584776..1585297 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CXX03_RS07900 Protein ID WP_001296726.1
Coordinates 1585297..1585563 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX03_RS07865 1580086..1581414 - 1329 WP_001716536.1 hypothetical protein -
CXX03_RS07870 1581470..1581745 - 276 WP_000116168.1 hypothetical protein -
CXX03_RS07875 1582039..1582374 - 336 WP_001181008.1 hypothetical protein -
CXX03_RS07880 1582384..1583580 - 1197 WP_000805824.1 replication initiation factor domain-containing protein -
CXX03_RS07885 1583580..1583777 - 198 WP_000017777.1 hypothetical protein -
CXX03_RS07890 1583915..1584127 + 213 WP_000712390.1 hypothetical protein -
CXX03_RS25950 1584430..1584603 + 174 WP_001409659.1 hypothetical protein -
CXX03_RS07895 1584776..1585297 - 522 WP_001716546.1 HipA N-terminal domain-containing protein Toxin
CXX03_RS07900 1585297..1585563 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
CXX03_RS07905 1585772..1589656 - 3885 Protein_1516 ECSE_1600 family autotransporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / espR1 / fimA / sodB 1352674..1742976 390302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-65)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19263.42 Da        Isoelectric Point: 10.4169

>T92323 WP_001716546.1 NZ_CP025892:c1585297-1584776 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLLISAFPVLGGTGIHI
SDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVL
RLHGRLSREYGSK

Download         Length: 522 bp

>T92323 NZ_CP025892:c1585297-1584776 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACTCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATC
AGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTT
TTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCGG
CAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTG
AGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT92323 WP_001296726.1 NZ_CP025892:c1585563-1585297 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT92323 NZ_CP025892:c1585563-1585297 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References