Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2805592..2806246 Replicon chromosome
Accession NZ_CP025881
Organism Escherichia coli strain 503440

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag CXX05_RS14205 Protein ID WP_000244772.1
Coordinates 2805592..2805999 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CXX05_RS14210 Protein ID WP_000354046.1
Coordinates 2805980..2806246 (-) Length 89 a.a.

Genomic Context

CXX05_RS14200CXX05_RS14215CXX05_RS14230CXX05_RS14185CXX05_RS14190CXX05_RS14195CXX05_RS14205CXX05_RS14210CXX05_RS14220CXX05_RS14225CXX05_RS14235
Location: 2805031..2805552 (522 bp)
Type: Others
Protein ID: WP_001055874.1
Location: 2806489..2807469 (981 bp)
Type: Others
Protein ID: WP_000886062.1
Location: 2808725..2810158 (1434 bp)
Type: Others
Protein ID: WP_001344773.1
Location: 2801549..2803282 (1734 bp)
Type: Others
Protein ID: WP_000813215.1
Location: 2803288..2803998 (711 bp)
Type: Others
Protein ID: WP_000715214.1
Location: 2804023..2804919 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 2805592..2805999 (408 bp)
Type: Toxin
Protein ID: WP_000244772.1
Location: 2805980..2806246 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 2807546..2808205 (660 bp)
Type: Others
Protein ID: WP_000250274.1
Location: 2808369..2808680 (312 bp)
Type: Others
Protein ID: WP_001182954.1
Location: 2810215..2810958 (744 bp)
Type: Others
Protein ID: WP_000951940.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CXX05_RS141852801549..2803282-1734WP_000813215.1single-stranded-DNA-specific exonuclease RecJ-
CXX05_RS141902803288..2803998-711WP_000715214.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
CXX05_RS141952804023..2804919-897WP_000806638.1site-specific tyrosine recombinase XerD-
CXX05_RS142002805031..2805552+522WP_001055874.1flavodoxin FldB-
CXX05_RS142052805592..2805999-408WP_000244772.1protein YgfXToxin
CXX05_RS142102805980..2806246-267WP_000354046.1FAD assembly factor SdhEAntitoxin
CXX05_RS142152806489..2807469+981WP_000886062.1tRNA-modifying protein YgfZ-
CXX05_RS142202807546..2808205-660WP_000250274.1hemolysin III family protein-
CXX05_RS142252808369..2808680-312WP_001182954.1N(4)-acetylcytidine aminohydrolase-
CXX05_RS142302808725..2810158+1434WP_001344773.16-phospho-beta-glucosidase BglA-
CXX05_RS142352810215..2810958-744WP_000951940.1SDR family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T92308 WP_000244772.1 NZ_CP025881:c2805999-2805592 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T92308 NZ_CP025881:c2805999-2805592 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT92308 WP_000354046.1 NZ_CP025881:c2806246-2805980 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT92308 NZ_CP025881:c2806246-2805980 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0XYB4

Antitoxin

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Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References