Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1208021..1208808 Replicon chromosome
Accession NZ_CP025881
Organism Escherichia coli strain 503440

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CXX05_RS05965 Protein ID WP_001716546.1
Coordinates 1208021..1208542 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CXX05_RS05970 Protein ID WP_001296726.1
Coordinates 1208542..1208808 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX05_RS05935 1203331..1204659 - 1329 WP_001716536.1 hypothetical protein -
CXX05_RS05940 1204715..1204990 - 276 WP_000116168.1 hypothetical protein -
CXX05_RS05945 1205284..1205619 - 336 WP_001181008.1 hypothetical protein -
CXX05_RS05950 1205629..1206825 - 1197 WP_000805824.1 replication initiation factor domain-containing protein -
CXX05_RS05955 1206825..1207022 - 198 WP_000017777.1 hypothetical protein -
CXX05_RS05960 1207160..1207372 + 213 WP_000712390.1 hypothetical protein -
CXX05_RS26710 1207675..1207848 + 174 WP_001409659.1 hypothetical protein -
CXX05_RS05965 1208021..1208542 - 522 WP_001716546.1 HipA N-terminal domain-containing protein Toxin
CXX05_RS05970 1208542..1208808 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
CXX05_RS05975 1209017..1212919 - 3903 WP_024171776.1 ECSE_1600 family autotransporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / espR1 / fimA / sodB 969395..1369212 399817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-65)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19263.42 Da        Isoelectric Point: 10.4169

>T92296 WP_001716546.1 NZ_CP025881:c1208542-1208021 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLLISAFPVLGGTGIHI
SDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVL
RLHGRLSREYGSK

Download         Length: 522 bp

>T92296 NZ_CP025881:c1208542-1208021 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACTCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATC
AGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTT
TTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCGG
CAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTG
AGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT92296 WP_001296726.1 NZ_CP025881:c1208808-1208542 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT92296 NZ_CP025881:c1208808-1208542 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References