Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3705894..3706738 Replicon chromosome
Accession NZ_CP025869
Organism Escherichia coli strain 503829

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag CXX08_RS18485 Protein ID WP_000854686.1
Coordinates 3705894..3706277 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag CXX08_RS18490 Protein ID WP_001285602.1
Coordinates 3706358..3706738 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX08_RS18445 3700896..3701387 - 492 WP_001297187.1 DUF1097 domain-containing protein -
CXX08_RS18450 3701489..3702043 - 555 WP_001001902.1 molecular chaperone YcdY -
CXX08_RS18455 3702067..3702804 - 738 WP_000283664.1 zinc-binding phosphatase -
CXX08_RS18460 3702859..3703797 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
CXX08_RS18470 3704268..3705110 - 843 WP_001431817.1 DUF4942 domain-containing protein -
CXX08_RS18475 3705195..3705392 - 198 WP_000839253.1 DUF957 domain-containing protein -
CXX08_RS18480 3705409..3705897 - 489 WP_001054233.1 hypothetical protein -
CXX08_RS18485 3705894..3706277 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
CXX08_RS18490 3706358..3706738 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXX08_RS18495 3706749..3707432 - 684 WP_000086768.1 hypothetical protein -
CXX08_RS18500 3707451..3707672 - 222 WP_000692298.1 DUF987 domain-containing protein -
CXX08_RS18505 3707735..3708211 - 477 WP_001186726.1 RadC family protein -
CXX08_RS18510 3708227..3708712 - 486 WP_000214307.1 antirestriction protein -
CXX08_RS18515 3708804..3709622 - 819 WP_001234732.1 DUF945 domain-containing protein -
CXX08_RS18525 3709722..3709955 - 234 WP_001119717.1 DUF905 family protein -
CXX08_RS18530 3710034..3710489 - 456 WP_001504120.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T92290 WP_000854686.1 NZ_CP025869:c3706277-3705894 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T92290 NZ_CP025869:c3706277-3705894 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT92290 WP_001285602.1 NZ_CP025869:c3706738-3706358 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT92290 NZ_CP025869:c3706738-3706358 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References