Detailed information of TA system TA092288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3173937..3174724
• Replicon: chromosome
• Accession: NZ_CP025869
• Organism: Escherichia coli strain 503829

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: CXX08_RS15775
• Protein ID: WP_001716546.1
• Coordinates: 3174203..3174724 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: CXX08_RS15770
• Protein ID: WP_001296726.1
• Coordinates: 3173937..3174203 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX08_RS15765	3169826..3173728	+	3903	WP_024171776.1	ECSE_1600 family autotransporter	-
CXX08_RS15770	3173937..3174203	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
CXX08_RS15775	3174203..3174724	+	522	WP_001716546.1	HipA N-terminal domain-containing protein	Toxin
CXX08_RS25900	3174897..3175070	-	174	WP_001409659.1	hypothetical protein	-
CXX08_RS15780	3175373..3175585	-	213	WP_000712390.1	hypothetical protein	-
CXX08_RS15785	3175723..3175920	+	198	WP_000017777.1	hypothetical protein	-
CXX08_RS15790	3175920..3177116	+	1197	WP_000805824.1	replication initiation factor domain-containing protein	-
CXX08_RS15795	3177126..3177461	+	336	WP_001181008.1	hypothetical protein	-
CXX08_RS15800	3177755..3178030	+	276	WP_000116168.1	hypothetical protein	-
CXX08_RS15805	3178086..3179414	+	1329	WP_001716536.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	fimA / espR1 / vgrG/tssI	3024179..3416204	392025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-65)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 19263.42 Da
• Isoelectric Point: 10.4169

>T92288 WP_001716546.1 NZ_CP025869:3174203-3174724 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLLISAFPVLGGTGIHI
SDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVL
RLHGRLSREYGSK

Nucleotide

• Length: 522 bp

>T92288 NZ_CP025869:3174203-3174724 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACTCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATC
AGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTT
TTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCGG
CAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTG
AGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT92288 WP_001296726.1 NZ_CP025869:3173937-3174203 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT92288 NZ_CP025869:3173937-3174203 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA