Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 855511..856302 Replicon chromosome
Accession NZ_CP025869
Organism Escherichia coli strain 503829

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CXX08_RS04105 Protein ID WP_001717032.1
Coordinates 855511..855936 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CXX08_RS04110 Protein ID WP_001296928.1
Coordinates 855967..856302 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX08_RS04085 852356..852742 - 387 WP_001270938.1 DUF2441 domain-containing protein -
CXX08_RS04090 853365..854096 - 732 WP_001216640.1 TIGR02646 family protein -
CXX08_RS04095 854093..854314 - 222 WP_126125326.1 hypothetical protein -
CXX08_RS04100 854299..855490 - 1192 Protein_770 AAA family ATPase -
CXX08_RS04105 855511..855936 - 426 WP_001717032.1 TA system toxin CbtA family protein Toxin
CXX08_RS04110 855967..856302 - 336 WP_001296928.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXX08_RS04115 856302..856775 - 474 WP_001296921.1 DNA repair protein RadC -
CXX08_RS04120 856805..857623 - 819 WP_001296926.1 DUF945 domain-containing protein -
CXX08_RS04125 857860..858813 - 954 WP_000290409.1 hypothetical protein -
CXX08_RS04130 859406..860020 + 615 WP_000772911.1 inovirus Gp2 family protein -
CXX08_RS04135 860138..860356 + 219 WP_001064742.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16522.19 Da        Isoelectric Point: 10.2369

>T92274 WP_001717032.1 NZ_CP025869:c855936-855511 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQILLARLLEQHYGLNLNDTPFNNEKVIQERIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDVLRARQATGLRIQCKNTNIISRMADSRHDKRLYQRTFKACKRCYYTKT

Download         Length: 426 bp

>T92274 NZ_CP025869:c855936-855511 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAATATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACGCATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAGTTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATGTTTTACGGGCGCGACAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12565.57 Da        Isoelectric Point: 7.7245

>AT92274 WP_001296928.1 NZ_CP025869:c856302-855967 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKHLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp

>AT92274 NZ_CP025869:c856302-855967 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACATCTGGAGCTGAAACTGGCTGACGGTGAACTCTCTCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References