Detailed information of TA system TA092245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 7744..8531
• Replicon: chromosome
• Accession: NZ_CP025865
• Organism: Escherichia coli strain 504211

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: CXX09_RS00030
• Protein ID: WP_001716546.1
• Coordinates: 8010..8531 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: CXX09_RS00025
• Protein ID: WP_001296726.1
• Coordinates: 7744..8010 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX09_RS00020	3633..7535	+	3903	WP_126133732.1	ECSE_1600 family autotransporter	-
CXX09_RS00025	7744..8010	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
CXX09_RS00030	8010..8531	+	522	WP_001716546.1	HipA N-terminal domain-containing protein	Toxin
CXX09_RS25925	8704..8877	-	174	WP_001409659.1	hypothetical protein	-
CXX09_RS00035	9180..9392	-	213	WP_000712390.1	hypothetical protein	-
CXX09_RS00040	9530..9727	+	198	WP_000017777.1	hypothetical protein	-
CXX09_RS00045	9727..10923	+	1197	WP_000805824.1	replication initiation factor domain-containing protein	-
CXX09_RS00050	10933..11268	+	336	WP_001181008.1	hypothetical protein	-
CXX09_RS00055	11562..11837	+	276	WP_000116168.1	hypothetical protein	-
CXX09_RS00060	11893..13221	+	1329	WP_001716536.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2743..11837	9094

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-65)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 19263.42 Da
• Isoelectric Point: 10.4169

>T92245 WP_001716546.1 NZ_CP025865:8010-8531 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLLISAFPVLGGTGIHI
SDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVL
RLHGRLSREYGSK

Nucleotide

• Length: 522 bp

>T92245 NZ_CP025865:8010-8531 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACTCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATC
AGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTT
TTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCGG
CAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTG
AGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT92245 WP_001296726.1 NZ_CP025865:7744-8010 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT92245 NZ_CP025865:7744-8010 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA