Detailed information of TA system TA092237

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3721073..3721871
• Replicon: chromosome
• Accession: NZ_CP025862
• Organism: Escherichia coli strain 504237

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CXX10_RS18500
• Protein ID: WP_000854733.1
• Coordinates: 3721494..3721871 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CXX10_RS18495
• Protein ID: WP_032190265.1
• Coordinates: 3721073..3721447 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX10_RS18460	3716357..3717928	+	1572	WP_000381395.1	IS66 family transposase	-
CXX10_RS18465	3717943..3718773	+	831	WP_024172271.1	DUF945 domain-containing protein	-
CXX10_RS18470	3718773..3719042	+	270	WP_001183319.1	hypothetical protein	-
CXX10_RS18475	3719111..3719584	+	474	WP_001355870.1	antirestriction protein	-
CXX10_RS18480	3719600..3720076	+	477	WP_001502867.1	RadC family protein	-
CXX10_RS18485	3720139..3720360	+	222	WP_000692327.1	DUF987 domain-containing protein	-
CXX10_RS18490	3720379..3721023	+	645	WP_000086771.1	hypothetical protein	-
CXX10_RS18495	3721073..3721447	+	375	WP_032190265.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CXX10_RS18500	3721494..3721871	+	378	WP_000854733.1	TA system toxin CbtA family protein	Toxin
CXX10_RS18505	3721868..3722356	+	489	WP_000761663.1	hypothetical protein	-
CXX10_RS18510	3722368..3722565	+	198	WP_000839243.1	DUF957 domain-containing protein	-
CXX10_RS26350	3722654..3723502	+	849	Protein_3552	DUF4942 domain-containing protein	-
CXX10_RS18530	3723573..3725108	+	1536	WP_000484448.1	EAL domain-containing protein	-
CXX10_RS18535	3725443..3725979	-	537	WP_000942799.1	GspM family type II secretion system protein YghD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC	3695172..3821727	126555

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14236.21 Da
• Isoelectric Point: 6.8528

>T92237 WP_000854733.1 NZ_CP025862:3721494-3721871 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T92237 NZ_CP025862:3721494-3721871 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTACTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13967.80 Da
• Isoelectric Point: 6.7388

>AT92237 WP_032190265.1 NZ_CP025862:3721073-3721447 [Escherichia coli]
VSDKLHETNYPDDHNDRIWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADSLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT92237 NZ_CP025862:3721073-3721447 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCATCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA