Detailed information of TA system TA092234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3119110..3119735
• Replicon: chromosome
• Accession: NZ_CP025862
• Organism: Escherichia coli strain 504237

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CXX10_RS15455
• Protein ID: WP_000911328.1
• Coordinates: 3119110..3119508 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U9XQV3
• Locus tag: CXX10_RS15460
• Protein ID: WP_000450524.1
• Coordinates: 3119508..3119735 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX10_RS15435	3114988..3115188	+	201	WP_000383836.1	YpfN family protein	-
CXX10_RS15440	3115298..3115996	-	699	WP_000679823.1	esterase	-
CXX10_RS15445	3116070..3118085	-	2016	WP_000829355.1	tRNA cytosine(34) acetyltransferase TmcA	-
CXX10_RS15450	3118100..3118963	-	864	WP_001267508.1	neutral zinc metallopeptidase	-
CXX10_RS15455	3119110..3119508	-	399	WP_000911328.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CXX10_RS15460	3119508..3119735	-	228	WP_000450524.1	toxin-antitoxin system antitoxin VapB	Antitoxin
CXX10_RS15465	3119889..3120602	-	714	WP_001295467.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CXX10_RS15470	3120815..3121849	-	1035	WP_001297320.1	outer membrane protein assembly factor BamC	-
CXX10_RS15475	3121866..3122744	-	879	WP_001295469.1	4-hydroxy-tetrahydrodipicolinate synthase	-
CXX10_RS15480	3122890..3123462	+	573	WP_000176187.1	glycine cleavage system transcriptional repressor	-
CXX10_RS15485	3123462..3123932	+	471	WP_001068682.1	thioredoxin-dependent thiol peroxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14966.32 Da
• Isoelectric Point: 8.5325

>T92234 WP_000911328.1 NZ_CP025862:c3119508-3119110 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYEAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Nucleotide

• Length: 399 bp

>T92234 NZ_CP025862:c3119508-3119110 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGAGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8498.61 Da
• Isoelectric Point: 4.3867

>AT92234 WP_000450524.1 NZ_CP025862:c3119735-3119508 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Nucleotide

• Length: 228 bp

>AT92234 NZ_CP025862:c3119735-3119508 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A829CM33