Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2590411..2591243 | Replicon | chromosome |
| Accession | NZ_CP025862 | ||
| Organism | Escherichia coli strain 504237 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | CXX10_RS12955 | Protein ID | WP_000854762.1 |
| Coordinates | 2590869..2591243 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | CXX10_RS12950 | Protein ID | WP_001295723.1 |
| Coordinates | 2590411..2590779 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CXX10_RS12915 | 2586450..2586923 | + | 474 | WP_000855059.1 | antirestriction protein | - |
| CXX10_RS12920 | 2586939..2587415 | + | 477 | WP_001186774.1 | RadC family protein | - |
| CXX10_RS12925 | 2587478..2587699 | + | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| CXX10_RS12935 | 2587888..2589501 | - | 1614 | WP_001744949.1 | IS66-like element ISEc47 family transposase | - |
| CXX10_RS12940 | 2589532..2589882 | - | 351 | WP_000624688.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CXX10_RS12945 | 2589879..2590313 | - | 435 | WP_001403014.1 | IS66 family insertion sequence hypothetical protein | - |
| CXX10_RS12950 | 2590411..2590779 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CXX10_RS12955 | 2590869..2591243 | + | 375 | WP_000854762.1 | TA system toxin CbtA family protein | Toxin |
| CXX10_RS12960 | 2591240..2591446 | + | 207 | WP_000976829.1 | hypothetical protein | - |
| CXX10_RS12965 | 2591459..2591572 | + | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| CXX10_RS12970 | 2591679..2592740 | - | 1062 | Protein_2487 | IS66-like element ISEc8 family transposase | - |
| CXX10_RS12975 | 2592790..2593137 | - | 348 | WP_000612588.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CXX10_RS12980 | 2593134..2593514 | - | 381 | WP_001171554.1 | IS66 family insertion sequence hypothetical protein | - |
| CXX10_RS12985 | 2593617..2594591 | + | 975 | WP_001433436.1 | IS21 family transposase | - |
| CXX10_RS12990 | 2594585..2595367 | + | 783 | WP_001667685.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| CXX10_RS26150 | 2595641..2595823 | + | 183 | WP_001667686.1 | ethanolamine utilization - propanediol utilization family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2541258..2599830 | 58572 | |
| - | inside | IScluster/Tn | - | - | 2587888..2599431 | 11543 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14094.15 Da Isoelectric Point: 7.1881
>T92232 WP_000854762.1 NZ_CP025862:2590869-2591243 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T92232 NZ_CP025862:2590869-2591243 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT92232 WP_001295723.1 NZ_CP025862:2590411-2590779 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT92232 NZ_CP025862:2590411-2590779 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|