Detailed information of TA system TA092195

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3299488..3300323
• Replicon: chromosome
• Accession: NZ_CP025859
• Organism: Escherichia coli strain 504239

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CXV92_RS16180
• Protein ID: WP_001487841.1
• Coordinates: 3299488..3299865 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CXV92_RS16185
• Protein ID: WP_001485190.1
• Coordinates: 3299955..3300323 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXV92_RS16160	3296534..3298030	-	1497	Protein_3100	EAL domain-containing protein	-
CXV92_RS16165	3298139..3298984	-	846	Protein_3101	DUF4942 domain-containing protein	-
CXV92_RS16170	3299069..3299266	-	198	WP_085950260.1	DUF957 domain-containing protein	-
CXV92_RS16175	3299294..3299491	-	198	Protein_3103	hypothetical protein	-
CXV92_RS16180	3299488..3299865	-	378	WP_001487841.1	TA system toxin CbtA family protein	Toxin
CXV92_RS16185	3299955..3300323	-	369	WP_001485190.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CXV92_RS16190	3300373..3301017	-	645	WP_001384112.1	hypothetical protein	-
CXV92_RS16195	3301036..3301257	-	222	WP_000692353.1	DUF987 domain-containing protein	-
CXV92_RS16200	3301326..3301802	-	477	WP_001462952.1	RadC family protein	-
CXV92_RS16205	3301818..3302303	-	486	WP_001462967.1	antirestriction protein	-
CXV92_RS16210	3302395..3303213	-	819	WP_001522407.1	DUF945 domain-containing protein	-
CXV92_RS16220	3303312..3303545	-	234	WP_001278282.1	DUF905 family protein	-
CXV92_RS16225	3303551..3304228	-	678	WP_001462753.1	hypothetical protein	-
CXV92_RS16230	3304347..3305231	-	885	WP_001384104.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14196.17 Da
• Isoelectric Point: 8.5163

>T92195 WP_001487841.1 NZ_CP025859:c3299865-3299488 [Escherichia coli]
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR

Nucleotide

• Length: 378 bp

>T92195 NZ_CP025859:c3299865-3299488 [Escherichia coli]
ATGAAAACATCACCCGATACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACTCCATTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTCTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCCGGGTTC
AGCACTTGTCCCCGCTCTCAGTTCATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCAG
CCACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13690.36 Da
• Isoelectric Point: 5.0696

>AT92195 WP_001485190.1 NZ_CP025859:c3300323-3299955 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT

Nucleotide

• Length: 369 bp

>AT92195 NZ_CP025859:c3300323-3299955 [Escherichia coli]
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTGCCGTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA