Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1608212..1609044 Replicon chromosome
Accession NZ_CP025859
Organism Escherichia coli strain 504239

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag CXV92_RS07955 Protein ID WP_001094452.1
Coordinates 1608670..1609044 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7I8Z144
Locus tag CXV92_RS07950 Protein ID WP_016255729.1
Coordinates 1608212..1608580 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV92_RS07920 1605634..1605867 + 234 WP_001117567.1 DUF905 family protein -
CXV92_RS07930 1605967..1606785 + 819 WP_001234594.1 DUF945 domain-containing protein -
CXV92_RS07935 1606877..1607362 + 486 WP_000213708.1 antirestriction protein -
CXV92_RS07940 1607377..1607853 + 477 WP_001484796.1 RadC family protein -
CXV92_RS07945 1607916..1608137 + 222 WP_000692315.1 DUF987 domain-containing protein -
CXV92_RS07950 1608212..1608580 + 369 WP_016255729.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXV92_RS07955 1608670..1609044 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
CXV92_RS07960 1609041..1609532 + 492 WP_000977086.1 hypothetical protein -
CXV92_RS07965 1609543..1609740 + 198 WP_000839264.1 DUF957 domain-containing protein -
CXV92_RS07970 1609825..1610670 + 846 WP_001280506.1 DUF4942 domain-containing protein -
CXV92_RS26425 1611404..1613655 + 2252 Protein_1534 alpha-amylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS 1606877..1655863 48986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T92189 WP_001094452.1 NZ_CP025859:1608670-1609044 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T92189 NZ_CP025859:1608670-1609044 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCTCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCACCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13750.53 Da        Isoelectric Point: 6.7395

>AT92189 WP_016255729.1 NZ_CP025859:1608212-1608580 [Escherichia coli]
VSDTLHETTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT92189 NZ_CP025859:1608212-1608580 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGA
GAACTGAATCCCCGTCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7I8Z144

References