Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 423693..424219 | Replicon | chromosome |
Accession | NZ_CP025859 | ||
Organism | Escherichia coli strain 504239 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | CXV92_RS02185 | Protein ID | WP_000323025.1 |
Coordinates | 423693..423980 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | CXV92_RS02190 | Protein ID | WP_000534858.1 |
Coordinates | 423980..424219 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CXV92_RS02140 | 418717..418932 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
CXV92_RS26570 | 419152..419322 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
CXV92_RS02145 | 419686..419901 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
CXV92_RS02150 | 420202..420414 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
CXV92_RS02155 | 420469..420558 | + | 90 | WP_120795389.1 | hypothetical protein | - |
CXV92_RS02160 | 420836..421588 | - | 753 | WP_001047135.1 | antitermination protein | - |
CXV92_RS02165 | 421602..422651 | - | 1050 | WP_001265200.1 | DUF968 domain-containing protein | - |
CXV92_RS02170 | 422653..422931 | - | 279 | WP_012304870.1 | hypothetical protein | - |
CXV92_RS02175 | 422998..423249 | - | 252 | WP_000980994.1 | hypothetical protein | - |
CXV92_RS02180 | 423466..423621 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
CXV92_RS02185 | 423693..423980 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
CXV92_RS02190 | 423980..424219 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
CXV92_RS02195 | 424244..424453 | + | 210 | Protein_424 | hypothetical protein | - |
CXV92_RS02200 | 424452..424580 | - | 129 | Protein_425 | dicB transcriptional regulator DicC | - |
CXV92_RS02205 | 424664..425071 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
CXV92_RS02210 | 425238..425393 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
CXV92_RS02215 | 425395..425970 | + | 576 | WP_000344953.1 | hypothetical protein | - |
CXV92_RS02220 | 426457..426645 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
CXV92_RS02225 | 426642..426833 | + | 192 | WP_001083278.1 | lysis protein YdfD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 394585..444053 | 49468 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T92179 WP_000323025.1 NZ_CP025859:c423980-423693 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T92179 NZ_CP025859:c423980-423693 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT92179 WP_000534858.1 NZ_CP025859:c424219-423980 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT92179 NZ_CP025859:c424219-423980 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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