Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 68124..68659 Replicon plasmid p504838_108
Accession NZ_CP025857
Organism Escherichia coli strain 504838

Toxin (Protein)


Gene name relE Uniprot ID A0A0M1UJC2
Locus tag CXV93_RS25895 Protein ID WP_001270422.1
Coordinates 68372..68659 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag CXV93_RS25890 Protein ID WP_001132895.1
Coordinates 68124..68375 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV93_RS25870 63554..64516 - 963 WP_000756328.1 ParB/RepB/Spo0J family partition protein -
CXV93_RS25875 64513..65718 - 1206 WP_000817635.1 AAA family ATPase -
CXV93_RS25880 65980..66252 + 273 WP_001695087.1 hypothetical protein -
CXV93_RS25885 66233..67441 + 1209 WP_001695118.1 IS91 family transposase -
CXV93_RS25890 68124..68375 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CXV93_RS25895 68372..68659 + 288 WP_001270422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXV93_RS25900 68661..69072 + 412 Protein_88 DDE-type integrase/transposase/recombinase -
CXV93_RS25910 69716..70693 + 978 WP_000361613.1 RepB family plasmid replication initiator protein -
CXV93_RS25915 70936..71676 - 741 WP_001066944.1 tyrosine-type recombinase/integrase -
CXV93_RS25920 71797..71925 - 129 WP_032164396.1 hypothetical protein -
CXV93_RS25930 72888..73193 + 306 WP_000336590.1 major pilus subunit operon regulatory protein PapB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - cofA 1..108475 108475


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.30 Da        Isoelectric Point: 10.4703

>T92171 WP_001270422.1 NZ_CP025857:68372-68659 [Escherichia coli]
MRYQVKFREDALKEWQKMDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T92171 NZ_CP025857:68372-68659 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT92171 WP_001132895.1 NZ_CP025857:68124-68375 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT92171 NZ_CP025857:68124-68375 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M1UJC2

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References