Detailed information of TA system TA092156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3255138..3255769
• Replicon: chromosome
• Accession: NZ_CP025856
• Organism: Escherichia coli strain 504838

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9Y2A7
• Locus tag: CXV93_RS15935
• Protein ID: WP_001259385.1
• Coordinates: 3255138..3255413 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CXV93_RS15940
• Protein ID: WP_126125540.1
• Coordinates: 3255410..3255769 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXV93_RS15920	3250142..3251209	+	1068	WP_000361467.1	HlyD family secretion protein	-
CXV93_RS15925	3251206..3253941	+	2736	WP_000149165.1	ribosome-associated ATPase/putative transporter RbbA	-
CXV93_RS15930	3253941..3255065	+	1125	WP_001314210.1	ABC transporter permease	-
CXV93_RS15935	3255138..3255413	+	276	WP_001259385.1	type II toxin-antitoxin system HicA family toxin	Toxin
CXV93_RS15940	3255410..3255769	+	360	WP_126125540.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CXV93_RS15945	3255819..3256679	-	861	WP_001131783.1	class II aldolase	-
CXV93_RS15950	3256711..3256980	-	270	WP_000933060.1	HPr family phosphocarrier protein	-
CXV93_RS15955	3256970..3258478	-	1509	WP_001298718.1	carbohydrate kinase	-
CXV93_RS15960	3258471..3259829	-	1359	WP_001298729.1	PTS galactitol transporter subunit IIC	-
CXV93_RS15965	3259906..3260187	-	282	WP_000084022.1	PTS sugar transporter subunit IIB	-
CXV93_RS15970	3260184..3260657	-	474	WP_001161553.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3240076..3262028	21952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10199.94 Da
• Isoelectric Point: 10.7076

>T92156 WP_001259385.1 NZ_CP025856:3255138-3255413 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Nucleotide

• Length: 276 bp

>T92156 NZ_CP025856:3255138-3255413 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13389.27 Da
• Isoelectric Point: 4.8838

>AT92156 WP_126125540.1 NZ_CP025856:3255410-3255769 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAATQQQVSVNTYIIETLNERLNHL

Nucleotide

• Length: 360 bp

>AT92156 NZ_CP025856:3255410-3255769 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTACGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A0A4P7TTW8