Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 997908..998752 Replicon chromosome
Accession NZ_CP025856
Organism Escherichia coli strain 504838

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag CXV93_RS05230 Protein ID WP_000854686.1
Coordinates 997908..998291 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag CXV93_RS05235 Protein ID WP_001285602.1
Coordinates 998372..998752 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV93_RS05190 992910..993401 - 492 WP_001297187.1 DUF1097 domain-containing protein -
CXV93_RS05195 993503..994057 - 555 WP_001001902.1 molecular chaperone YcdY -
CXV93_RS05200 994081..994818 - 738 WP_000283664.1 zinc-binding phosphatase -
CXV93_RS05205 994873..995811 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
CXV93_RS05215 996282..997124 - 843 WP_001696893.1 DUF4942 domain-containing protein -
CXV93_RS05220 997209..997406 - 198 WP_000839253.1 DUF957 domain-containing protein -
CXV93_RS05225 997423..997911 - 489 WP_001696892.1 hypothetical protein -
CXV93_RS05230 997908..998291 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
CXV93_RS05235 998372..998752 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXV93_RS05240 998763..999446 - 684 WP_001696891.1 hypothetical protein -
CXV93_RS05245 999465..999686 - 222 WP_001696890.1 DUF987 domain-containing protein -
CXV93_RS05250 999749..1000225 - 477 WP_001186726.1 RadC family protein -
CXV93_RS05255 1000241..1000726 - 486 WP_001697217.1 antirestriction protein -
CXV93_RS05260 1000818..1001636 - 819 WP_001697216.1 DUF945 domain-containing protein -
CXV93_RS05270 1001736..1001969 - 234 WP_001119719.1 DUF905 family protein -
CXV93_RS05275 1002048..1002502 - 455 Protein_1026 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgC / csgA / csgB / csgD / csgE / csgF / csgG 988405..1011461 23056


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T92149 WP_000854686.1 NZ_CP025856:c998291-997908 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T92149 NZ_CP025856:c998291-997908 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT92149 WP_001285602.1 NZ_CP025856:c998752-998372 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT92149 NZ_CP025856:c998752-998372 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References