Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 81290..81825 Replicon plasmid p510016_84
Accession NZ_CP025855
Organism Escherichia coli strain 510016

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CXX11_RS26095 Protein ID WP_001270421.1
Coordinates 81538..81825 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CXX11_RS26090 Protein ID WP_001399716.1
Coordinates 81290..81541 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX11_RS26055 76790..77311 + 522 Protein_94 IS91 family transposase -
CXX11_RS26060 77651..78613 - 963 WP_000756325.1 ParB/RepB/Spo0J family partition protein -
CXX11_RS26065 78610..79815 - 1206 WP_000817642.1 AAA family ATPase -
CXX11_RS26075 80195..80407 + 213 WP_001399715.1 hypothetical protein -
CXX11_RS26085 80583..81041 + 459 WP_123001294.1 IS200/IS605 family transposase -
CXX11_RS26090 81290..81541 + 252 WP_001399716.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CXX11_RS26095 81538..81825 + 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXX11_RS26100 81827..81949 + 123 Protein_101 IS3 family transposase -
CXX11_RS26110 82027..82299 + 273 WP_001423410.1 hypothetical protein -
CXX11_RS26115 82280..83488 + 1209 WP_001510762.1 IS91 family transposase -
CXX11_RS26120 83726..83877 - 152 Protein_104 transcriptional regulator -
CXX11_RS26125 84348..84647 + 300 WP_024169928.1 adhesin biosynthesis transcription regulatory family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cofA / csaA / csaB / csaC / csaE / cfaD' 1..84977 84977
- inside IScluster/Tn - - 65843..83488 17645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T92139 WP_001270421.1 NZ_CP025855:81538-81825 [Escherichia coli]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T92139 NZ_CP025855:81538-81825 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9204.51 Da        Isoelectric Point: 4.0785

>AT92139 WP_001399716.1 NZ_CP025855:81290-81541 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLYDVDLD
KYL

Download         Length: 252 bp

>AT92139 NZ_CP025855:81290-81541 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGATGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGTATGATGTAGACTTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References