Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 62135..62682 Replicon plasmid p510016_84
Accession NZ_CP025855
Organism Escherichia coli strain 510016

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CXX11_RS25940 Protein ID WP_001399798.1
Coordinates 62401..62682 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag CXX11_RS25935 Protein ID WP_000079934.1
Coordinates 62135..62404 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX11_RS25895 58102..58287 - 186 Protein_69 ethanolamine utilization protein EutE -
CXX11_RS25900 58462..59159 + 698 Protein_70 IS1 family transposase -
CXX11_RS25905 59176..59655 - 480 Protein_71 transcription termination factor NusG -
CXX11_RS25920 60357..61229 + 873 WP_001399800.1 incFII family plasmid replication initiator RepA -
CXX11_RS26360 61922..62080 + 159 WP_001399797.1 hypothetical protein -
CXX11_RS25935 62135..62404 + 270 WP_000079934.1 hypothetical protein Antitoxin
CXX11_RS25940 62401..62682 + 282 WP_001399798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXX11_RS25945 62728..63576 + 849 WP_001399799.1 3'-5' exonuclease -
CXX11_RS25960 64340..64966 + 627 WP_021511696.1 hypothetical protein -
CXX11_RS25965 64963..65532 + 570 Protein_78 DNA helicase -
CXX11_RS25970 65578..65850 - 273 WP_000566440.1 hypothetical protein -
CXX11_RS25975 65843..66313 - 471 WP_126125721.1 recombinase family protein -
CXX11_RS25980 66354..67526 + 1173 WP_126125662.1 IS21-like element ISEc62 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cofA / csaA / csaB / csaC / csaE / cfaD' 1..84977 84977
- flank IS/Tn - - 58462..58737 275
- inside IScluster/Tn - - 65843..83488 17645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 7.2749

>T92138 WP_001399798.1 NZ_CP025855:62401-62682 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGCVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T92138 NZ_CP025855:62401-62682 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGTCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCCGCCAGCAGCCTGGCAGGGCAGCCGTATAAAGGCCGCAACGGTT
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10214.53 Da        Isoelectric Point: 8.8735

>AT92138 WP_000079934.1 NZ_CP025855:62135-62404 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLSHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT92138 NZ_CP025855:62135-62404 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGATCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGCCAGCAACTTGAGCGCGGTGATGTGCTTTCCCATGACATGGTCGAATCCTCAGCTACCGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References