Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 33221..33768 Replicon plasmid p510016_84
Accession NZ_CP025855
Organism Escherichia coli strain 510016

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CXX11_RS25710 Protein ID WP_001399798.1
Coordinates 33221..33502 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag CXX11_RS25715 Protein ID WP_000079934.1
Coordinates 33499..33768 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX11_RS25675 28397..29482 + 1086 WP_001401504.1 CS4 pilus tip adhesin CsaE -
CXX11_RS25680 29645..30296 - 652 Protein_33 helix-turn-helix transcriptional regulator -
CXX11_RS25685 30353..31050 + 698 Protein_34 IS1 family transposase -
CXX11_RS25695 31551..32248 + 698 Protein_35 IS1 family transposase -
CXX11_RS25705 32578..33072 - 495 WP_001404491.1 GNAT family N-acetyltransferase -
CXX11_RS25710 33221..33502 - 282 WP_001399798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXX11_RS25715 33499..33768 - 270 WP_000079934.1 hypothetical protein Antitoxin
CXX11_RS26345 33823..33981 - 159 WP_001399797.1 hypothetical protein -
CXX11_RS25730 34489..34761 - 273 WP_000566440.1 hypothetical protein -
CXX11_RS25735 34754..35224 - 471 WP_126125721.1 recombinase family protein -
CXX11_RS25740 35265..36437 + 1173 WP_126125722.1 IS21-like element ISEc62 family transposase -
CXX11_RS25745 36437..37223 + 787 Protein_43 IS21-like element helper ATPase IstB -
CXX11_RS25750 37281..37622 + 342 Protein_44 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cofA / csaA / csaB / csaC / csaE / cfaD' 1..84977 84977
- inside IScluster/Tn - - 30353..48063 17710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 7.2749

>T92137 WP_001399798.1 NZ_CP025855:c33502-33221 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGCVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T92137 NZ_CP025855:c33502-33221 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGTCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCCGCCAGCAGCCTGGCAGGGCAGCCGTATAAAGGCCGCAACGGTT
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10214.53 Da        Isoelectric Point: 8.8735

>AT92137 WP_000079934.1 NZ_CP025855:c33768-33499 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLSHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT92137 NZ_CP025855:c33768-33499 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGATCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGCCAGCAACTTGAGCGCGGTGATGTGCTTTCCCATGACATGGTCGAATCCTCAGCTACCGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References