92136

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 13206..13671 Replicon plasmid p510016_36
Accession NZ_CP025853
Organism Escherichia coli strain 510016

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag CXX11_RS24840 Protein ID WP_001230707.1
Coordinates 13420..13671 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag CXX11_RS24835 Protein ID WP_000801440.1
Coordinates 13206..13433 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX11_RS24785 8613..8828 - 216 WP_000760375.1 EexN family lipoprotein -
CXX11_RS24790 8825..9118 - 294 WP_000134733.1 LuxR family transcriptional regulator -
CXX11_RS24795 9195..10424 - 1230 WP_000539543.1 relaxase/mobilization nuclease domain-containing protein -
CXX11_RS24800 10428..10931 - 504 WP_000781814.1 hypothetical protein -
CXX11_RS24810 11291..11422 - 132 WP_001353745.1 toxin-antitoxin system HicB family antitoxin -
CXX11_RS24815 11719..12030 - 312 WP_000627400.1 hypothetical protein -
CXX11_RS24820 12027..12443 - 417 WP_012421208.1 tail-associated lysozyme -
CXX11_RS24825 12453..12752 - 300 WP_000650311.1 hypothetical protein -
CXX11_RS24835 13206..13433 - 228 WP_000801440.1 hypothetical protein Antitoxin
CXX11_RS24840 13420..13671 - 252 WP_001230707.1 hypothetical protein Toxin
CXX11_RS24845 13668..14210 - 543 WP_001083906.1 hypothetical protein -
CXX11_RS24850 14315..14830 - 516 WP_001025395.1 J domain-containing protein -
CXX11_RS24860 15470..15820 - 351 WP_000127482.1 addiction module antitoxin -
CXX11_RS24865 15817..16152 - 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -
CXX11_RS24870 17407..18273 + 867 WP_001353743.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA1 - 1..36521 36521


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T92136 WP_001230707.1 NZ_CP025853:c13671-13420 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T92136 NZ_CP025853:c13671-13420 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT92136 WP_000801440.1 NZ_CP025853:c13433-13206 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT92136 NZ_CP025853:c13433-13206 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References