Detailed information of TA system TA092130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): itaRT/DUF1778(antitoxin)
• Location: 3757914..3758751
• Replicon: chromosome
• Accession: NZ_CP025851
• Organism: Escherichia coli strain 510016

Toxin (Protein)

• Gene name: itaT
• Uniprot ID: Q3Z4X7
• Locus tag: CXX11_RS18680
• Protein ID: WP_000227784.1
• Coordinates: 3757914..3758456 (-)
• Length: 181 a.a.

Antitoxin (Protein)

• Gene name: itaR
• Uniprot ID: I2UQS9
• Locus tag: CXX11_RS18685
• Protein ID: WP_001297137.1
• Coordinates: 3758440..3758751 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX11_RS18655	3752917..3753507	-	591	WP_001276309.1	protein deglycase YajL	-
CXX11_RS18660	3753470..3754381	-	912	WP_000705853.1	2-dehydropantoate 2-reductase	-
CXX11_RS18665	3754549..3755040	+	492	WP_001138904.1	nucleotide binding protein YajQ	-
CXX11_RS18670	3755168..3756532	-	1365	WP_001000978.1	MFS transporter	-
CXX11_RS18675	3756939..3757858	+	920	Protein_3571	sel1 repeat family protein	-
CXX11_RS18680	3757914..3758456	-	543	WP_000227784.1	GNAT family N-acetyltransferase	Toxin
CXX11_RS18685	3758440..3758751	-	312	WP_001297137.1	DUF1778 domain-containing protein	Antitoxin
CXX11_RS18690	3758936..3759826	-	891	WP_000971336.1	heme o synthase	-
CXX11_RS18695	3759838..3760167	-	330	WP_000019869.1	cytochrome o ubiquinol oxidase subunit IV	-
CXX11_RS18700	3760167..3760781	-	615	WP_000179819.1	cytochrome o ubiquinol oxidase subunit III	-
CXX11_RS18705	3760771..3762762	-	1992	WP_000467180.1	cytochrome o ubiquinol oxidase subunit I	-
CXX11_RS18710	3762784..3763731	-	948	WP_001239440.1	cytochrome o ubiquinol oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (68-156)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-97)

Sequences

Toxin

Protein

• Length: 181 a.a.
• Molecular weight: 19805.02 Da
• Isoelectric Point: 8.3395

>T92130 WP_000227784.1 NZ_CP025851:c3758456-3757914 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Nucleotide

• Length: 543 bp

>T92130 NZ_CP025851:c3758456-3757914 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11358.04 Da
• Isoelectric Point: 10.4825

>AT92130 WP_001297137.1 NZ_CP025851:c3758751-3758440 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Nucleotide

• Length: 312 bp

>AT92130 NZ_CP025851:c3758751-3758440 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• PDB: 7BYY

Antitoxin

• AlphaFold DB: A0A0E0Y6B3