Detailed information of TA system TA092088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 126718..127253
• Replicon: plasmid p602354_148
• Accession: NZ_CP025848
• Organism: Escherichia coli strain 602354

Toxin (Protein)

• Gene name: relE
• Uniprot ID: T2HS21
• Locus tag: CXX15_RS25770
• Protein ID: WP_000222775.1
• Coordinates: 126718..127005 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: T2HSA2
• Locus tag: CXX15_RS25775
• Protein ID: WP_001139207.1
• Coordinates: 127002..127253 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX15_RS25720	121956..122336	+	381	WP_001171554.1	IS66 family insertion sequence hypothetical protein	-
CXX15_RS25725	122333..122680	+	348	WP_000612591.1	IS66 family insertion sequence element accessory protein TnpB	-
CXX15_RS25730	122730..124268	+	1539	WP_000998069.1	IS66 family transposase	-
CXX15_RS26235	124307..124555	-	249	Protein_151	hypothetical protein	-
CXX15_RS25745	124909..125511	+	603	WP_000517689.1	hypothetical protein	-
CXX15_RS26240	126163..126708	-	546	WP_000926983.1	hypothetical protein	-
CXX15_RS25770	126718..127005	-	288	WP_000222775.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CXX15_RS25775	127002..127253	-	252	WP_001139207.1	plasmid stabilization protein	Antitoxin
CXX15_RS26155	127340..127507	-	168	WP_000841011.1	hypothetical protein	-
CXX15_RS25785	128208..129065	-	858	WP_000130987.1	incFII family plasmid replication initiator RepA	-
CXX15_RS25790	129058..129132	-	75	WP_001365705.1	RepA leader peptide Tap	-
CXX15_RS25800	129377..129625	-	249	WP_000083840.1	replication regulatory protein RepA	-
CXX15_RS25805	129865..130455	-	591	WP_000766827.1	DUF2726 domain-containing protein	-
CXX15_RS25810	130493..130702	-	210	WP_001353639.1	transcriptional regulator	-
CXX15_RS25815	130748..131209	-	462	WP_001233850.1	thermonuclease family protein	-
CXX15_RS25820	131455..131667	-	213	WP_001301409.1	ANR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	csfA / cssA	1..148526	148526

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11142.17 Da
• Isoelectric Point: 10.6261

>T92088 WP_000222775.1 NZ_CP025848:c127005-126718 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Nucleotide

• Length: 288 bp

>T92088 NZ_CP025848:c127005-126718 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGTGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9216.45 Da
• Isoelectric Point: 4.0927

>AT92088 WP_001139207.1 NZ_CP025848:c127253-127002 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT92088 NZ_CP025848:c127253-127002 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAC
AGTTATTTATGA

Structures

Toxin

• AlphaFold DB: T2HS21

Antitoxin

• AlphaFold DB: A0A754EQ65