Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4870803..4871635 Replicon chromosome
Accession NZ_CP025847
Organism Escherichia coli strain 602354

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CXX15_RS23940 Protein ID WP_000854762.1
Coordinates 4871261..4871635 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag CXX15_RS23935 Protein ID WP_001295723.1
Coordinates 4870803..4871171 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX15_RS23900 4866842..4867315 + 474 WP_000855059.1 antirestriction protein -
CXX15_RS23905 4867331..4867807 + 477 WP_001186774.1 RadC family protein -
CXX15_RS23910 4867870..4868091 + 222 WP_000692341.1 DUF987 domain-containing protein -
CXX15_RS23920 4868280..4869893 - 1614 WP_001744949.1 IS66-like element ISEc47 family transposase -
CXX15_RS23925 4869924..4870274 - 351 WP_000624688.1 IS66 family insertion sequence element accessory protein TnpB -
CXX15_RS23930 4870271..4870705 - 435 WP_001403014.1 IS66 family insertion sequence hypothetical protein -
CXX15_RS23935 4870803..4871171 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXX15_RS23940 4871261..4871635 + 375 WP_000854762.1 TA system toxin CbtA family protein Toxin
CXX15_RS23945 4871632..4871838 + 207 WP_000976829.1 hypothetical protein -
CXX15_RS23950 4871851..4871964 + 114 WP_001161660.1 DUF957 domain-containing protein -
CXX15_RS23955 4872071..4873132 - 1062 Protein_4594 IS66-like element ISEc8 family transposase -
CXX15_RS23960 4873182..4873529 - 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
CXX15_RS23965 4873526..4873906 - 381 WP_001171554.1 IS66 family insertion sequence hypothetical protein -
CXX15_RS23970 4874009..4874983 + 975 WP_001433436.1 IS21 family transposase -
CXX15_RS23975 4874977..4875759 + 783 WP_001667685.1 IS21-like element IS100kyp family helper ATPase IstB -
CXX15_RS23985 4876033..4876215 + 183 WP_001667686.1 ethanolamine utilization - propanediol utilization family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4868280..4886721 18441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14094.15 Da        Isoelectric Point: 7.1881

>T92084 WP_000854762.1 NZ_CP025847:4871261-4871635 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T92084 NZ_CP025847:4871261-4871635 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT92084 WP_001295723.1 NZ_CP025847:4870803-4871171 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT92084 NZ_CP025847:4870803-4871171 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References