Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3079825..3080443 Replicon chromosome
Accession NZ_CP025847
Organism Escherichia coli strain 602354

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CXX15_RS14740 Protein ID WP_001291435.1
Coordinates 3079825..3080043 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CXX15_RS14745 Protein ID WP_000344800.1
Coordinates 3080069..3080443 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX15_RS14705 3075114..3075686 + 573 WP_000779831.1 YbaY family lipoprotein -
CXX15_RS14710 3075717..3076028 - 312 WP_000409911.1 MGMT family protein -
CXX15_RS14720 3076407..3076760 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CXX15_RS14725 3076802..3078352 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CXX15_RS14730 3078516..3078986 - 471 WP_000136192.1 YlaC family protein -
CXX15_RS14735 3079102..3079653 - 552 WP_000102568.1 maltose O-acetyltransferase -
CXX15_RS14740 3079825..3080043 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CXX15_RS14745 3080069..3080443 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CXX15_RS14750 3080989..3084138 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
CXX15_RS14755 3084161..3085354 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T92068 WP_001291435.1 NZ_CP025847:c3080043-3079825 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T92068 NZ_CP025847:c3080043-3079825 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT92068 WP_000344800.1 NZ_CP025847:c3080443-3080069 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT92068 NZ_CP025847:c3080443-3080069 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References