Detailed information of TA system TA092056

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 937973..938771
• Replicon: chromosome
• Accession: NZ_CP025847
• Organism: Escherichia coli strain 602354

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CXX15_RS04520
• Protein ID: WP_000854733.1
• Coordinates: 938394..938771 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CXX15_RS04515
• Protein ID: WP_032190265.1
• Coordinates: 937973..938347 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX15_RS04475	933100..934713	-	1614	WP_001744949.1	IS66-like element ISEc47 family transposase	-
CXX15_RS04480	934744..935094	-	351	WP_000624688.1	IS66 family insertion sequence element accessory protein TnpB	-
CXX15_RS04485	935091..935525	-	435	WP_001403014.1	IS66 family insertion sequence hypothetical protein	-
CXX15_RS04490	935673..935942	+	270	WP_001183319.1	hypothetical protein	-
CXX15_RS04495	936011..936484	+	474	WP_001355870.1	antirestriction protein	-
CXX15_RS04500	936500..936976	+	477	WP_001502867.1	RadC family protein	-
CXX15_RS04505	937039..937260	+	222	WP_000692327.1	DUF987 domain-containing protein	-
CXX15_RS04510	937279..937923	+	645	WP_000086771.1	hypothetical protein	-
CXX15_RS04515	937973..938347	+	375	WP_032190265.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CXX15_RS04520	938394..938771	+	378	WP_000854733.1	TA system toxin CbtA family protein	Toxin
CXX15_RS04525	938768..939256	+	489	WP_000761663.1	hypothetical protein	-
CXX15_RS04530	939268..939465	+	198	WP_000839243.1	DUF957 domain-containing protein	-
CXX15_RS26180	939554..940402	+	849	Protein_865	DUF4942 domain-containing protein	-
CXX15_RS04550	940473..942008	+	1536	WP_000484448.1	EAL domain-containing protein	-
CXX15_RS04555	942343..942879	-	537	WP_000942799.1	GspM family type II secretion system protein YghD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14236.21 Da
• Isoelectric Point: 6.8528

>T92056 WP_000854733.1 NZ_CP025847:938394-938771 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T92056 NZ_CP025847:938394-938771 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTACTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13967.80 Da
• Isoelectric Point: 6.7388

>AT92056 WP_032190265.1 NZ_CP025847:937973-938347 [Escherichia coli]
VSDKLHETNYPDDHNDRIWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADSLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT92056 NZ_CP025847:937973-938347 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCATCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA