Detailed information of TA system TA092044

Bioinformatically predicted

Overview

TA module

• Type: V
• Classification (family/domain): ghoTS/ghoT-GhoS
• Location: 2587129..2587626
• Replicon: chromosome
• Accession: NZ_CP025842
• Organism: Escherichia coli strain 720632

Toxin (Protein)

• Gene name: ghoT
• Uniprot ID: L4JJG6
• Locus tag: CXX37_RS13210
• Protein ID: WP_001173343.1
• Coordinates: 2587129..2587302 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: ghoS
• Uniprot ID: -
• Locus tag: CXX37_RS13215
• Protein ID: WP_072280288.1
• Coordinates: 2587330..2587626 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXX37_RS13195	2584009..2585427	+	1419	WP_074638465.1	dipeptide/tripeptide permease DtpC	-
CXX37_RS13200	2585515..2586671	+	1157	WP_085948186.1	IS3-like element IS600 family transposase	-
CXX37_RS13205	2586715..2587005	+	291	Protein_2539	lysine--tRNA ligase	-
CXX37_RS13210	2587129..2587302	-	174	WP_001173343.1	type V toxin-antitoxin system toxin GhoT	Toxin
CXX37_RS13215	2587330..2587626	-	297	WP_072280288.1	type V toxin-antitoxin system endoribonuclease antitoxin GhoS	Antitoxin
CXX37_RS13220	2587853..2588125	-	273	WP_000405647.1	N-acetyltransferase	-
CXX37_RS13225	2588137..2588367	-	231	WP_044782310.1	(4Fe-4S)-binding protein	-
CXX37_RS13230	2588548..2590179	+	1632	WP_001216477.1	sensor histidine kinase	-
CXX37_RS13235	2590176..2590895	+	720	WP_000611288.1	two-component system response regulator DcuR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6555.06 Da
• Isoelectric Point: 10.2288

>T92044 WP_001173343.1 NZ_CP025842:c2587302-2587129 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Nucleotide

• Length: 174 bp

>T92044 NZ_CP025842:c2587302-2587129 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11482.00 Da
• Isoelectric Point: 4.1705

>AT92044 WP_072280288.1 NZ_CP025842:c2587626-2587330 [Escherichia coli]
MEGKNKFNTYIVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Nucleotide

• Length: 297 bp

>AT92044 NZ_CP025842:c2587626-2587330 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATATTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A7U9QI41