Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 43429..44003 Replicon plasmid p214_4_132
Accession NZ_CP025841
Organism Escherichia coli strain 214-4

Toxin (Protein)


Gene name relE Uniprot ID A0A0S3PMZ8
Locus tag CXX41_RS25850 Protein ID WP_001595119.1
Coordinates 43677..44003 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S3PN98
Locus tag CXX41_RS25845 Protein ID WP_001595120.1
Coordinates 43429..43680 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXX41_RS25810 38486..38908 + 423 WP_001595126.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
CXX41_RS25815 38908..40182 + 1275 WP_001595125.1 Y-family DNA polymerase -
CXX41_RS26850 40221..40544 - 324 WP_207212908.1 hypothetical protein -
CXX41_RS25825 40541..40954 - 414 WP_032159708.1 hypothetical protein -
CXX41_RS25830 40978..42009 - 1032 WP_001595123.1 ParB/RepB/Spo0J family partition protein -
CXX41_RS25835 42009..42875 - 867 WP_001595122.1 AAA family ATPase -
CXX41_RS25845 43429..43680 + 252 WP_001595120.1 hypothetical protein Antitoxin
CXX41_RS25850 43677..44003 + 327 WP_001595119.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXX41_RS25855 44038..44403 + 366 WP_129547473.1 transposase -
CXX41_RS25860 44403..45580 + 1178 Protein_54 IS91 family transposase -
CXX41_RS25875 46453..47430 + 978 WP_023486339.1 RepB family plasmid replication initiator protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cssA / cofA / faeD / faeE / estIa 1..132527 132527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12187.44 Da        Isoelectric Point: 10.4373

>T92026 WP_001595119.1 NZ_CP025841:43677-44003 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAIGK
RERSDVYNLASRVGSLAAAACHGLKLPL

Download         Length: 327 bp

>T92026 NZ_CP025841:43677-44003 [Escherichia coli]
ATGACTTACACAGTCAAATTCAGGGATGATGCACTGAAAGAATGGCTGAAACTGGATAAGGCCATTCAACAGCAATTTGC
TAAAAAGCTAAAGAAGTGCAGTGAAAATCCTCATATTCCCTCTGCTAAGCTGCGCGGGATAAAAGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTAGTCTATCAGGTGATAGATGATCAATTAATTATCGCTGTTGTTGCTATTGGGAAA
CGTGAACGTAGTGATGTTTATAATCTTGCCAGCCGAGTAGGCAGCCTGGCGGCTGCGGCTTGTCATGGACTGAAATTACC
GTTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9144.43 Da        Isoelectric Point: 4.2975

>AT92026 WP_001595120.1 NZ_CP025841:43429-43680 [Escherichia coli]
MPNIILTDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYGKMLDAMDDQELVKLVAERSNQKLHDVDLD
SYL

Download         Length: 252 bp

>AT92026 NZ_CP025841:43429-43680 [Escherichia coli]
ATGCCTAACATCATTCTTACCGACACAAGCGCCAGTGTAAGCGAACTTAAGAAAAACCCGATGGCTACAGTCAGCGCTGG
TGATGGCTACCCAGTTGCTATTCTGAACCGCAACCAGCCAGCCTTTTACTGCGTACCCGCAGAGTTGTACGGAAAGATGC
TCGATGCCATGGACGATCAGGAACTGGTTAAGCTAGTCGCCGAACGCAGCAACCAGAAGCTGCACGATGTGGATCTGGAT
AGCTACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3PMZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3PN98

References