Detailed information of TA system TA092002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1600625..1601287
• Replicon: chromosome
• Accession: NZ_CP025838
• Organism: Streptococcus pneumoniae strain SPN XDR SMC1710-32

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C1H54_RS08665
• Protein ID: WP_000192224.1
• Coordinates: 1601114..1601287 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: C1H54_RS08660
• Protein ID: WP_000961810.1
• Coordinates: 1600625..1601077 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1H54_RS08635	1596515..1597258	-	744	WP_001188208.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
C1H54_RS08640	1597260..1598210	-	951	WP_000451131.1	50S ribosomal protein L11 methyltransferase	-
C1H54_RS08645	1598348..1598776	-	429	WP_000418156.1	NUDIX hydrolase	-
C1H54_RS08650	1598757..1599845	-	1089	WP_000719724.1	M50 family metallopeptidase	-
C1H54_RS08655	1599864..1600334	-	471	WP_000257097.1	DUF3013 family protein	-
C1H54_RS08660	1600625..1601077	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C1H54_RS08665	1601114..1601287	-	174	WP_000192224.1	type II toxin-antitoxin system HicA family toxin	Toxin
C1H54_RS08670	1601430..1601609	-	180	WP_001809903.1	hypothetical protein	-
C1H54_RS08680	1601774..1602013	-	240	WP_000818079.1	hypothetical protein	-
C1H54_RS08690	1602283..1603554	+	1272	WP_001113216.1	replication-associated recombination protein A	-
C1H54_RS08700	1604098..1605417	-	1320	WP_000502554.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6386.51 Da
• Isoelectric Point: 10.8214

>T92002 WP_000192224.1 NZ_CP025838:c1601287-1601114 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 174 bp

>T92002 NZ_CP025838:c1601287-1601114 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATGGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT92002 WP_000961810.1 NZ_CP025838:c1601077-1600625 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT92002 NZ_CP025838:c1601077-1600625 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: G0IC64