Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1600625..1601287 Replicon chromosome
Accession NZ_CP025838
Organism Streptococcus pneumoniae strain SPN XDR SMC1710-32

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C1H54_RS08665 Protein ID WP_000192224.1
Coordinates 1601114..1601287 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag C1H54_RS08660 Protein ID WP_000961810.1
Coordinates 1600625..1601077 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H54_RS08635 1596515..1597258 - 744 WP_001188208.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
C1H54_RS08640 1597260..1598210 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
C1H54_RS08645 1598348..1598776 - 429 WP_000418156.1 NUDIX hydrolase -
C1H54_RS08650 1598757..1599845 - 1089 WP_000719724.1 M50 family metallopeptidase -
C1H54_RS08655 1599864..1600334 - 471 WP_000257097.1 DUF3013 family protein -
C1H54_RS08660 1600625..1601077 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1H54_RS08665 1601114..1601287 - 174 WP_000192224.1 type II toxin-antitoxin system HicA family toxin Toxin
C1H54_RS08670 1601430..1601609 - 180 WP_001809903.1 hypothetical protein -
C1H54_RS08680 1601774..1602013 - 240 WP_000818079.1 hypothetical protein -
C1H54_RS08690 1602283..1603554 + 1272 WP_001113216.1 replication-associated recombination protein A -
C1H54_RS08700 1604098..1605417 - 1320 WP_000502554.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6386.51 Da        Isoelectric Point: 10.8214

>T92002 WP_000192224.1 NZ_CP025838:c1601287-1601114 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

>T92002 NZ_CP025838:c1601287-1601114 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATGGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT92002 WP_000961810.1 NZ_CP025838:c1601077-1600625 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT92002 NZ_CP025838:c1601077-1600625 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References