Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1076088..1076586 Replicon chromosome
Accession NZ_CP025838
Organism Streptococcus pneumoniae strain SPN XDR SMC1710-32

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag C1H54_RS05720 Protein ID WP_001809704.1
Coordinates 1076088..1076342 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag C1H54_RS05725 Protein ID WP_000208080.1
Coordinates 1076344..1076586 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H54_RS05705 1071361..1073829 - 2469 WP_050197910.1 DNA gyrase subunit A -
C1H54_RS05710 1074023..1075009 + 987 WP_000204727.1 L-lactate dehydrogenase -
C1H54_RS05715 1075346..1076041 - 696 WP_000731137.1 potassium channel family protein -
C1H54_RS05720 1076088..1076342 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H54_RS05725 1076344..1076586 - 243 WP_000208080.1 hypothetical protein Antitoxin
C1H54_RS05730 1076780..1078036 + 1257 WP_000530078.1 ISL3 family transposase -
C1H54_RS05735 1078100..1078909 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
C1H54_RS05740 1078911..1080260 - 1350 WP_100910888.1 cell wall metabolism sensor histidine kinase VicK -
C1H54_RS05745 1080253..1080957 - 705 WP_000722076.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1076780..1078036 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T92000 WP_001809704.1 NZ_CP025838:c1076342-1076088 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T92000 NZ_CP025838:c1076342-1076088 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT92000 WP_000208080.1 NZ_CP025838:c1076586-1076344 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT92000 NZ_CP025838:c1076586-1076344 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References