Detailed information of TA system TA091984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 752400..753738
• Replicon: chromosome
• Accession: NZ_CP025800
• Organism: Yersinia ruckeri strain SC09

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: NJ56_RS03400
• Protein ID: WP_038275283.1
• Coordinates: 752400..753350 (-)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A848MNT5
• Locus tag: NJ56_RS03405
• Protein ID: WP_038245317.1
• Coordinates: 753343..753738 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NJ56_RS03380	749208..749900	-	693	WP_038245321.1	membrane protein	-
NJ56_RS03385	749948..751102	-	1155	WP_038245380.1	N-acetylneuraminate epimerase	-
NJ56_RS03395	751766..752050	-	285	WP_038245319.1	antirestriction protein	-
NJ56_RS03400	752400..753350	-	951	WP_038275283.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NJ56_RS03405	753343..753738	-	396	WP_038245317.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NJ56_RS03410	753813..754043	-	231	WP_073990333.1	DUF4942 domain-containing protein	-
NJ56_RS03415	754193..754321	+	129	Protein_650	helix-turn-helix domain-containing protein	-
NJ56_RS03420	754357..754455	+	99	Protein_651	transposase	-
NJ56_RS03425	754469..754759	-	291	Protein_652	transposase	-
NJ56_RS03430	754764..755162	+	399	Protein_653	DDE-type integrase/transposase/recombinase	-
NJ56_RS03435	755181..755467	-	287	Protein_654	hypothetical protein	-
NJ56_RS03440	755488..756555	-	1068	WP_038275274.1	macro domain-containing protein	-
NJ56_RS03445	756552..757208	-	657	WP_038275272.1	DUF4433 domain-containing protein	-
NJ56_RS03450	757211..757786	-	576	WP_038275270.1	DUF4433 domain-containing protein	-
NJ56_RS03455	757833..758300	-	468	WP_052173072.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	754469..754717	248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-304)

Antitoxin

• Protein of unknown function DUF6088 (10-114)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 36088.43 Da
• Isoelectric Point: 4.5996

>T91984 WP_038275283.1 NZ_CP025800:c753350-752400 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Nucleotide

• Length: 951 bp

>T91984 NZ_CP025800:c753350-752400 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTATGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAAGACGTGGACATTAAGCTTGTCCCCGTCGCTGGTTTTACCCAG
CAATATTCCAGAGGCCAGCGTAAAGACATTCGTAAGGGTATTATTCGGACCGTTATCGAAACGATTACAGCTTCAGGTAC
GTTTCGCATGGATGAAGGGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14406.76 Da
• Isoelectric Point: 11.0360

>AT91984 WP_038245317.1 NZ_CP025800:c753738-753343 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Nucleotide

• Length: 396 bp

>AT91984 NZ_CP025800:c753738-753343 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCCGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A848MNT5