Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 273214..273837 Replicon chromosome
Accession NZ_CP025800
Organism Yersinia ruckeri strain SC09

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag NJ56_RS01285 Protein ID WP_038243726.1
Coordinates 273634..273837 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag NJ56_RS01280 Protein ID WP_004718732.1
Coordinates 273214..273582 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJ56_RS01265 271468..271722 + 255 WP_038243728.1 type B 50S ribosomal protein L31 -
NJ56_RS01270 271742..271885 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
NJ56_RS18305 272004..272141 - 138 WP_155274690.1 hypothetical protein -
NJ56_RS01280 273214..273582 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
NJ56_RS01285 273634..273837 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
NJ56_RS01295 274646..274960 + 315 WP_004718728.1 MGMT family protein -
NJ56_RS01300 275338..276201 + 864 WP_004718726.1 acyl-CoA thioesterase II -
NJ56_RS01305 276316..277605 - 1290 WP_038275502.1 ammonium transporter AmtB -
NJ56_RS01310 277644..277982 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T91983 WP_038243726.1 NZ_CP025800:273634-273837 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T91983 NZ_CP025800:273634-273837 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT91983 WP_004718732.1 NZ_CP025800:273214-273582 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT91983 NZ_CP025800:273214-273582 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References