Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1664299..1664852 Replicon chromosome
Accession NZ_CP025799
Organism Dickeya zeae strain MS2

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag C1O30_RS07495 Protein ID WP_102801434.1
Coordinates 1664538..1664852 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K9QDB2
Locus tag C1O30_RS07490 Protein ID WP_049855373.1
Coordinates 1664299..1664535 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1O30_RS07470 1659990..1660775 + 786 WP_019844778.1 SDR family oxidoreductase -
C1O30_RS07475 1660884..1661696 + 813 WP_102801433.1 oxidoreductase -
C1O30_RS07480 1661873..1662865 + 993 WP_199770320.1 oxidoreductase -
C1O30_RS07485 1663054..1664055 + 1002 WP_038913604.1 NADP-dependent oxidoreductase -
C1O30_RS07490 1664299..1664535 + 237 WP_049855373.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C1O30_RS07495 1664538..1664852 + 315 WP_102801434.1 CcdB family protein Toxin
C1O30_RS07505 1665246..1666049 - 804 WP_102801435.1 carboxymuconolactone decarboxylase family protein -
C1O30_RS07510 1666065..1666760 - 696 WP_199770335.1 antibiotic biosynthesis monooxygenase -
C1O30_RS07515 1666820..1667839 - 1020 WP_102801436.1 aldo/keto reductase -
C1O30_RS07520 1667858..1668415 - 558 WP_102801437.1 NAD(P)H-dependent oxidoreductase -
C1O30_RS07525 1668568..1669602 - 1035 WP_102801438.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11462.36 Da        Isoelectric Point: 7.9859

>T91971 WP_102801434.1 NZ_CP025799:1664538-1664852 [Dickeya zeae]
MQFTVYGNTGKSGVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPAIRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAMDFLIDGI

Download         Length: 315 bp

>T91971 NZ_CP025799:1664538-1664852 [Dickeya zeae]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGGCGTTTACCCGTTATTGCTTGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGCCATCAGGCTGACGGACGGCAAGGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATTCCTGTGCAGGCTCTGGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGTAATCAGGTAAAGGCCGCCATGGATTTCCTCATCGACGGTATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9024.99 Da        Isoelectric Point: 5.1184

>AT91971 WP_049855373.1 NZ_CP025799:1664299-1664535 [Dickeya zeae]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEANKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT91971 NZ_CP025799:1664299-1664535 [Dickeya zeae]
ATGACCGCGAAACAACGTAACACGCAGAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGTGCCACGCTGTCAACCGCACTGGATGCGGAGCTTCGCCGTTATGAGGCGAACAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGCTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QDB2

References