Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 700988..701666 Replicon chromosome
Accession NZ_CP025799
Organism Dickeya zeae strain MS2

Toxin (Protein)


Gene name cptA Uniprot ID D2BSA8
Locus tag C1O30_RS03225 Protein ID WP_012883372.1
Coordinates 701235..701666 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2K9QKF2
Locus tag C1O30_RS03220 Protein ID WP_016943577.1
Coordinates 700988..701254 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1O30_RS03205 698150..698758 - 609 WP_019846260.1 HD domain-containing protein -
C1O30_RS03210 698971..699621 + 651 WP_038913159.1 hemolysin III family protein -
C1O30_RS03215 699698..700678 - 981 WP_102801018.1 tRNA-modifying protein YgfZ -
C1O30_RS03220 700988..701254 + 267 WP_016943577.1 FAD assembly factor SdhE Antitoxin
C1O30_RS03225 701235..701666 + 432 WP_012883372.1 protein YgfX Toxin
C1O30_RS03230 701755..702273 - 519 WP_016943578.1 flavodoxin FldB -
C1O30_RS03235 702450..703775 - 1326 WP_102802665.1 MHS family MFS transporter -
C1O30_RS03240 704039..704938 + 900 WP_016943580.1 site-specific tyrosine recombinase XerD -
C1O30_RS03245 705025..705741 + 717 WP_019846265.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16887.54 Da        Isoelectric Point: 11.5023

>T91969 WP_012883372.1 NZ_CP025799:701235-701666 [Dickeya zeae]
VAQWQCDLRVSWRMQLFSLLTHGFLMLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRSIKSRQGEISLRGDNQLHWQQR
DWQIVRRPWFMRNGVLLSLRAVDGKGQQRLWLASDSMGSEEWRLLRQQLQQPALHGTESSRHH

Download         Length: 432 bp

>T91969 NZ_CP025799:701235-701666 [Dickeya zeae]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGTTGTTTTCGCTGCTAACGCACGGATTTCTGATGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTACGCGCCGCTGTGGCTCGGGTTAGTGACGCTGGTCGTGTTTGACTTTG
TGCGTAGCCAGCGAAGCATCAAATCGCGCCAGGGGGAGATTTCCCTGCGTGGCGATAACCAACTGCACTGGCAGCAACGT
GACTGGCAGATTGTCCGGCGACCATGGTTCATGCGCAACGGCGTATTGTTATCGCTACGTGCGGTGGATGGTAAAGGGCA
ACAGCGTTTGTGGCTGGCATCAGATAGTATGGGGAGTGAGGAATGGCGGCTGTTACGTCAACAGCTGCAGCAGCCTGCGC
TGCATGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10404.88 Da        Isoelectric Point: 5.5981

>AT91969 WP_016943577.1 NZ_CP025799:700988-701254 [Dickeya zeae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPGDPGLKRMVSLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT91969 NZ_CP025799:700988-701254 [Dickeya zeae]
ATGGACATCAATAACAAAGCACGTATTCACTGGGCGTGCAGGCGTGGAATGCGCGAACTGGACATCTCTATCATGCCGTT
TTTCGAGCATGAGTACGATACGCTGAGCGACGACGACAAGCAGCAGTTTATTCGTCTGCTGCAGTGTGACGATCCCGACT
TGTTTAATTGGTTGATGAACCACGGCGAGCCGGGTGATCCCGGTTTGAAGCGGATGGTTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K9QB06

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QKF2

References