Detailed information of TA system TA091967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 580333..581111
• Replicon: chromosome
• Accession: NZ_CP025799
• Organism: Dickeya zeae strain MS2

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: C1O30_RS02650
• Protein ID: WP_102800985.1
• Coordinates: 580623..581111 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A2K9QAQ0
• Locus tag: C1O30_RS02645
• Protein ID: WP_038903249.1
• Coordinates: 580333..580626 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1O30_RS02620	575493..576704	+	1212	WP_102800980.1	glycosyltransferase family 4 protein	-
C1O30_RS02625	576706..577809	+	1104	WP_102800981.1	glycosyltransferase family 4 protein	-
C1O30_RS02630	577856..578263	+	408	WP_102800982.1	hypothetical protein	-
C1O30_RS02635	578301..579695	+	1395	WP_102800983.1	DUF4832 domain-containing protein	-
C1O30_RS02640	579725..580225	+	501	WP_102800984.1	serine acetyltransferase	-
C1O30_RS02645	580333..580626	+	294	WP_038903249.1	DUF1778 domain-containing protein	Antitoxin
C1O30_RS02650	580623..581111	+	489	WP_102800985.1	GNAT family N-acetyltransferase	Toxin
C1O30_RS02655	581269..583470	+	2202	WP_102800986.1	AAA family ATPase	-
C1O30_RS02660	583841..584146	-	306	WP_102800987.1	type II toxin-antitoxin system toxin CcdB	-
C1O30_RS02665	584149..584367	-	219	WP_102800988.1	type II toxin-antitoxin system antitoxin CcdA	-
C1O30_RS02675	585042..585617	-	576	WP_102800989.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-95)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17467.28 Da
• Isoelectric Point: 7.2147

>T91967 WP_102800985.1 NZ_CP025799:580623-581111 [Dickeya zeae]
MISAPEPLRAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNFAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEARAFYLQVGFEPSLIDPMMLMVTLGDLVG
SV

Nucleotide

• Length: 489 bp

>T91967 NZ_CP025799:580623-581111 [Dickeya zeae]
ATGATCTCAGCCCCTGAGCCACTCCGTGCCGAACATGTACTTTCCTCATTCTGTTGCGGCGTGGAGTCCATGGACAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGAGCATCACGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGCGCCGTAGCAACGAATTTCGCCCCTGGGCGCTTTCGCCGCAATATGCCCGATCCGATT
CCGGTAGTAGTGCTGGGACGTCTGGCGGTGGATACGTCATTGCATGGTCAGGGCGTTGGTCGGGCGCTGGTACGGGACGC
TGGGTTGCGGGTGATTCAGGTGGCGGATACTATCGGTATTCGCGGGATGTTGGTTCATGCGCTGTCTGATGAGGCGAGAG
CATTTTACCTACAGGTGGGGTTTGAGCCTTCACTGATAGATCCGATGATGCTGATGGTGACGTTGGGGGATTTGGTTGGG
AGTGTTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10902.47 Da
• Isoelectric Point: 10.1968

>AT91967 WP_038903249.1 NZ_CP025799:580333-580626 [Dickeya zeae]
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLTRLDQAPSPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT91967 NZ_CP025799:580333-580626 [Dickeya zeae]
ATGCCAGCGACGAACAGCGTTTCAGTTAAACGCGAAACATTGAATTTACGCATCAAGCCCGCCGAACGCGATCTGATAGA
TCGCGCTGCGAAGGCCAGAGGAAAAAATCGTACTGATTTTGTCCTCGAAGCTGCTCGAGCTGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATTATCATGGCAGATCCCGATGCTTATCAGGAATTCCTCACCCGTTTGGATCAGGCTCCTTCACCAAAT
GCTGCGCTGCGAAAAACCATGCAAACGCCTGCACCGTGGGAACAGAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2K9QAQ0