Detailed information of TA system TA091966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 165425..165990
• Replicon: chromosome
• Accession: NZ_CP025794
• Organism: Vibrio hyugaensis strain 090810a

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C1S74_RS01615
• Protein ID: WP_045403448.1
• Coordinates: 165703..165990 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: C1S74_RS01610
• Protein ID: WP_000086647.1
• Coordinates: 165425..165706 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1S74_RS01555	160425..160793	+	369	WP_045403454.1	hypothetical protein	-
C1S74_RS01560	160790..160900	+	111	WP_079883027.1	DUF3265 domain-containing protein	-
C1S74_RS01565	160953..161567	+	615	WP_045403471.1	hypothetical protein	-
C1S74_RS01580	162177..162308	+	132	WP_082039111.1	DUF3265 domain-containing protein	-
C1S74_RS01585	162357..163466	-	1110	WP_052437323.1	hypothetical protein	-
C1S74_RS01590	163711..164172	+	462	WP_045403452.1	hypothetical protein	-
C1S74_RS01600	164745..164903	+	159	WP_197064564.1	DUF3265 domain-containing protein	-
C1S74_RS01610	165425..165706	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C1S74_RS01615	165703..165990	+	288	WP_045403448.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C1S74_RS26500	166017..166109	+	93	WP_197064563.1	DUF3265 domain-containing protein	-
C1S74_RS01625	166167..166677	-	511	Protein_285	hypothetical protein	-
C1S74_RS01630	166674..167740	-	1067	Protein_286	PAAR domain-containing protein	-
C1S74_RS01635	167970..168446	+	477	Protein_287	NUDIX hydrolase	-
C1S74_RS01640	168926..169156	-	231	WP_038872158.1	PAS factor family protein	-
C1S74_RS01645	169624..170205	+	582	WP_052437322.1	DUF1287 domain-containing protein	-
C1S74_RS01650	170220..170882	+	663	WP_045403430.1	peptidase E	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11013.71 Da
• Isoelectric Point: 5.1098

>T91966 WP_045403448.1 NZ_CP025794:165703-165990 [Vibrio hyugaensis]
MKVVWSPLALQKLGDAAEFISLDNPPVAEKWVNEVFDKTELLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T91966 NZ_CP025794:165703-165990 [Vibrio hyugaensis]
ATGAAAGTCGTCTGGTCTCCATTAGCGCTTCAGAAGCTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGT
GGCAGAAAAGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATTCCCCATACGAACTATCGAGAAATCATCTTTGGTCACTATCGTATTATCTACAGCTTAAGCCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTGTCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT91966 WP_000086647.1 NZ_CP025794:165425-165706 [Vibrio hyugaensis]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT91966 NZ_CP025794:165425-165706 [Vibrio hyugaensis]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCTGGTGTAGCTTCATACATCAAACAAAT
TAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGTAAAGGTGTTGCTGTCGTTCTTGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAATTAGCTTCTGGTCTTGGTGTTTCCAAT
GATGATGCGCGTGCCCAAGTACTGGGGCGCATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0