Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 148034..148581 Replicon chromosome
Accession NZ_CP025794
Organism Vibrio hyugaensis strain 090810a

Toxin (Protein)


Gene name relE Uniprot ID A0A0C1WCT1
Locus tag C1S74_RS01410 Protein ID WP_020196829.1
Coordinates 148279..148581 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag C1S74_RS01405 Protein ID WP_005448240.1
Coordinates 148034..148291 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1S74_RS01340 143346..143435 + 90 WP_072612530.1 DUF3265 domain-containing protein -
C1S74_RS01350 143923..144054 + 132 WP_017420680.1 DUF3265 domain-containing protein -
C1S74_RS01355 144081..144467 + 387 WP_045398047.1 hypothetical protein -
C1S74_RS01360 144464..144574 + 111 WP_082039007.1 DUF3265 domain-containing protein -
C1S74_RS01365 145029..145121 + 93 WP_197064541.1 DUF3265 domain-containing protein -
C1S74_RS26495 145278..145529 + 252 WP_082039006.1 hypothetical protein -
C1S74_RS01375 145651..145740 + 90 WP_082039005.1 DUF3265 domain-containing protein -
C1S74_RS01380 145780..146181 + 402 WP_031856960.1 hypothetical protein -
C1S74_RS01385 146191..146373 + 183 WP_045398041.1 hypothetical protein -
C1S74_RS01390 146506..147063 + 558 WP_045398039.1 nucleotidyltransferase family protein -
C1S74_RS01395 147213..147845 + 633 WP_052437291.1 hypothetical protein -
C1S74_RS01400 147860..147952 + 93 WP_005445734.1 DUF3265 domain-containing protein -
C1S74_RS01405 148034..148291 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1S74_RS01410 148279..148581 + 303 WP_020196829.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1S74_RS01415 148617..148709 + 93 WP_080607091.1 DUF3265 domain-containing protein -
C1S74_RS01420 148747..149274 + 528 WP_045398038.1 hypothetical protein -
C1S74_RS01425 149300..149392 + 93 WP_193784364.1 DUF3265 domain-containing protein -
C1S74_RS01435 149882..150013 + 132 WP_082039002.1 DUF3265 domain-containing protein -
C1S74_RS01445 150586..151086 + 501 WP_045401129.1 hypothetical protein -
C1S74_RS01450 151245..151337 + 93 WP_082037751.1 DUF3265 domain-containing protein -
C1S74_RS01455 151380..151922 + 543 WP_045401126.1 hypothetical protein -
C1S74_RS01460 151944..152036 + 93 WP_079771126.1 DUF3265 domain-containing protein -
C1S74_RS01465 152140..152400 + 261 WP_045401125.1 hypothetical protein -
C1S74_RS01470 152544..152810 + 267 WP_045401122.1 barstar family protein -
C1S74_RS01475 153027..153329 - 303 WP_045467054.1 hypothetical protein -
C1S74_RS01480 153416..153547 + 132 WP_080931675.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 44410..164172 119762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11659.53 Da        Isoelectric Point: 5.1765

>T91965 WP_020196829.1 NZ_CP025794:148279-148581 [Vibrio hyugaensis]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPSELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T91965 NZ_CP025794:148279-148581 [Vibrio hyugaensis]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAT
CCGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT91965 WP_005448240.1 NZ_CP025794:148034-148291 [Vibrio hyugaensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT91965 NZ_CP025794:148034-148291 [Vibrio hyugaensis]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGATAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1WCT1

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References