Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 123372..123888 Replicon chromosome
Accession NZ_CP025794
Organism Vibrio hyugaensis strain 090810a

Toxin (Protein)


Gene name relB Uniprot ID A0A2S7V073
Locus tag C1S74_RS01110 Protein ID WP_045399167.1
Coordinates 123619..123888 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U2ZH00
Locus tag C1S74_RS01105 Protein ID WP_005526636.1
Coordinates 123372..123626 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1S74_RS01045 118478..118588 + 111 WP_103415315.1 DUF3265 domain-containing protein -
C1S74_RS01050 118616..118969 + 354 WP_045399180.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
C1S74_RS01055 119122..119736 + 615 WP_045399177.1 hypothetical protein -
C1S74_RS01060 120307..120399 + 93 WP_080936824.1 DUF3265 domain-containing protein -
C1S74_RS01065 120435..121022 + 588 WP_045399176.1 DUF1311 domain-containing protein -
C1S74_RS01070 121044..121136 + 93 WP_078555033.1 DUF3265 domain-containing protein -
C1S74_RS01075 121156..121716 + 561 WP_045399174.1 hypothetical protein -
C1S74_RS01080 121720..121836 + 117 WP_082039043.1 DUF3265 domain-containing protein -
C1S74_RS01085 121872..122552 + 681 WP_045399172.1 hypothetical protein -
C1S74_RS01090 122567..122659 + 93 WP_197064549.1 DUF3265 domain-containing protein -
C1S74_RS01100 123138..123269 + 132 WP_082039040.1 DUF3265 domain-containing protein -
C1S74_RS01105 123372..123626 + 255 WP_005526636.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C1S74_RS01110 123619..123888 + 270 WP_045399167.1 Txe/YoeB family addiction module toxin Toxin
C1S74_RS01115 124478..124570 + 93 WP_167391139.1 DUF3265 domain-containing protein -
C1S74_RS01120 124670..124972 - 303 WP_045467054.1 hypothetical protein -
C1S74_RS01125 125059..125190 + 132 WP_082037785.1 DUF3265 domain-containing protein -
C1S74_RS01130 125640..126461 + 822 WP_045401135.1 DUF1669 domain-containing protein -
C1S74_RS26610 126992..127081 + 90 WP_140291437.1 DUF3265 domain-containing protein -
C1S74_RS01140 127118..127699 + 582 WP_045401133.1 DJ-1/PfpI family protein -
C1S74_RS01145 127722..127814 + 93 WP_197064553.1 DUF3265 domain-containing protein -
C1S74_RS01150 127852..128526 + 675 WP_045401137.1 class I SAM-dependent methyltransferase -
C1S74_RS01155 128539..128664 + 126 WP_082039070.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 44410..164172 119762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10613.97 Da        Isoelectric Point: 8.8578

>T91963 WP_045399167.1 NZ_CP025794:123619-123888 [Vibrio hyugaensis]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDNQAI
TIISCRYHY

Download         Length: 270 bp

>T91963 NZ_CP025794:123619-123888 [Vibrio hyugaensis]
ATGAGTAGTAGTCAACGTTTACTATCGTGGACTGATGATGCTTGGGATGATTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATCGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCCGGTTTTTGGTCTCGTCGTATTGATGACACTAATAGGCTTGTTTACGCAGTCGATAATCAAGCGATA
ACGATAATTTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 5.0623

>AT91963 WP_005526636.1 NZ_CP025794:123372-123626 [Vibrio hyugaensis]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT91963 NZ_CP025794:123372-123626 [Vibrio hyugaensis]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTGAAAGCTGTTTTGGATGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAAGATGCAGTGGTTATGTCTTTAGACTATTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S7V073

Antitoxin

Source ID Structure
AlphaFold DB A0A244CM06

References