Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 85258..85786 Replicon chromosome
Accession NZ_CP025792
Organism Vibrio jasicida 090810c

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag C1S73_RS00560 Protein ID WP_005377002.1
Coordinates 85258..85548 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag C1S73_RS00565 Protein ID WP_005377003.1
Coordinates 85538..85786 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1S73_RS00490 80416..80505 + 90 WP_193788887.1 DUF3265 domain-containing protein -
C1S73_RS00495 80961..81053 + 93 WP_017821981.1 DUF3265 domain-containing protein -
C1S73_RS00500 81083..81406 + 324 WP_038873916.1 hypothetical protein -
C1S73_RS00505 81561..81893 + 333 WP_038873913.1 hypothetical protein -
C1S73_RS00510 81911..82000 + 90 WP_110178323.1 DUF3265 domain-containing protein -
C1S73_RS00515 82029..82307 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
C1S73_RS00520 82304..82588 - 285 WP_038873907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C1S73_RS00525 82665..82756 + 92 Protein_100 DUF3265 domain-containing protein -
C1S73_RS00530 83275..83364 + 90 WP_071652537.1 DUF3265 domain-containing protein -
C1S73_RS00535 83394..84011 + 618 WP_038873993.1 LysE family translocator -
C1S73_RS27970 84032..84124 + 93 WP_072833120.1 DUF3265 domain-containing protein -
C1S73_RS00550 84700..85110 + 411 WP_025543567.1 hypothetical protein -
C1S73_RS00560 85258..85548 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1S73_RS00565 85538..85786 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1S73_RS27975 85861..85929 + 69 WP_074531725.1 DUF3265 domain-containing protein -
C1S73_RS00570 85998..86669 + 672 WP_038873169.1 hypothetical protein -
C1S73_RS00575 86711..86803 + 93 WP_193788889.1 DUF3265 domain-containing protein -
C1S73_RS00580 86916..87236 + 321 WP_025523864.1 DUF4160 domain-containing protein -
C1S73_RS00585 87214..87459 + 246 WP_025523863.1 DUF2442 domain-containing protein -
C1S73_RS00595 88038..88169 + 132 WP_080765041.1 DUF3265 domain-containing protein -
C1S73_RS00600 88354..88569 + 216 WP_173399961.1 hypothetical protein -
C1S73_RS00605 88661..88780 + 120 WP_081634819.1 DUF3265 domain-containing protein -
C1S73_RS00610 88812..89270 + 459 WP_038873759.1 GNAT family N-acetyltransferase -
C1S73_RS00615 89266..89388 + 123 WP_081634818.1 DUF3265 domain-containing protein -
C1S73_RS00620 89415..89819 + 405 WP_038873755.1 hypothetical protein -
C1S73_RS00625 89834..89926 + 93 WP_081634816.1 DUF3265 domain-containing protein -
C1S73_RS00630 89956..90573 + 618 WP_038873217.1 LysE family translocator -
C1S73_RS00635 90570..90686 + 117 Protein_120 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 20661..506870 486209
- inside Integron - - 51072..111164 60092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T91961 WP_005377002.1 NZ_CP025792:c85548-85258 [Vibrio jasicida 090810c]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T91961 NZ_CP025792:c85548-85258 [Vibrio jasicida 090810c]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCAGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAGTCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT91961 WP_005377003.1 NZ_CP025792:c85786-85538 [Vibrio jasicida 090810c]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT91961 NZ_CP025792:c85786-85538 [Vibrio jasicida 090810c]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAATCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCCGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References