Detailed information of TA system TA091960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 82029..82588
• Replicon: chromosome
• Accession: NZ_CP025792
• Organism: Vibrio jasicida 090810c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A347UR22
• Locus tag: C1S73_RS00515
• Protein ID: WP_005398411.1
• Coordinates: 82029..82307 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C1S73_RS00520
• Protein ID: WP_038873907.1
• Coordinates: 82304..82588 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1S73_RS00450	77065..77391	+	327	WP_038871223.1	hypothetical protein	-
C1S73_RS00455	77787..78305	+	519	WP_038871216.1	hypothetical protein	-
C1S73_RS00460	78329..78418	+	90	WP_193788886.1	DUF3265 domain-containing protein	-
C1S73_RS00470	79018..79431	+	414	WP_038871220.1	RDD family protein	-
C1S73_RS00475	79453..79542	+	90	WP_079878804.1	DUF3265 domain-containing protein	-
C1S73_RS00485	79946..80038	+	93	WP_079400415.1	DUF3265 domain-containing protein	-
C1S73_RS00490	80416..80505	+	90	WP_193788887.1	DUF3265 domain-containing protein	-
C1S73_RS00495	80961..81053	+	93	WP_017821981.1	DUF3265 domain-containing protein	-
C1S73_RS00500	81083..81406	+	324	WP_038873916.1	hypothetical protein	-
C1S73_RS00505	81561..81893	+	333	WP_038873913.1	hypothetical protein	-
C1S73_RS00510	81911..82000	+	90	WP_110178323.1	DUF3265 domain-containing protein	-
C1S73_RS00515	82029..82307	-	279	WP_005398411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
C1S73_RS00520	82304..82588	-	285	WP_038873907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C1S73_RS00525	82665..82756	+	92	Protein_100	DUF3265 domain-containing protein	-
C1S73_RS00530	83275..83364	+	90	WP_071652537.1	DUF3265 domain-containing protein	-
C1S73_RS00535	83394..84011	+	618	WP_038873993.1	LysE family translocator	-
C1S73_RS27970	84032..84124	+	93	WP_072833120.1	DUF3265 domain-containing protein	-
C1S73_RS00550	84700..85110	+	411	WP_025543567.1	hypothetical protein	-
C1S73_RS00560	85258..85548	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C1S73_RS00565	85538..85786	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C1S73_RS27975	85861..85929	+	69	WP_074531725.1	DUF3265 domain-containing protein	-
C1S73_RS00570	85998..86669	+	672	WP_038873169.1	hypothetical protein	-
C1S73_RS00575	86711..86803	+	93	WP_193788889.1	DUF3265 domain-containing protein	-
C1S73_RS00580	86916..87236	+	321	WP_025523864.1	DUF4160 domain-containing protein	-
C1S73_RS00585	87214..87459	+	246	WP_025523863.1	DUF2442 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611	20661..506870	486209
	-	inside	Integron	-	-	51072..111164	60092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T91960 WP_005398411.1 NZ_CP025792:c82307-82029 [Vibrio jasicida 090810c]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T91960 NZ_CP025792:c82307-82029 [Vibrio jasicida 090810c]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGAGGACGATTACTCATCATTCCTGAAATTTCGATGATTGTCTCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11041.39 Da
• Isoelectric Point: 9.1865

>AT91960 WP_038873907.1 NZ_CP025792:c82588-82304 [Vibrio jasicida 090810c]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKAKIRNRGKQ

Nucleotide

• Length: 285 bp

>AT91960 NZ_CP025792:c82588-82304 [Vibrio jasicida 090810c]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAAAATCCGTAATCGAGGTAAGCAATGA

Structures

Toxin

• AlphaFold DB: A0A347UR22