Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 66046..67682 Replicon chromosome
Accession NZ_CP025781
Organism Iodobacter fluviatilis strain PCH194

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C1H71_RS00355 Protein ID WP_130108082.1
Coordinates 66046..67347 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C1H71_RS00360 Protein ID WP_130104791.1
Coordinates 67386..67682 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H71_RS00325 61295..62305 + 1011 WP_130104786.1 nucleoid-associated protein -
C1H71_RS00330 62566..62760 + 195 WP_130104787.1 hypothetical protein -
C1H71_RS00335 62817..63314 - 498 WP_188053452.1 GNAT family N-acetyltransferase -
C1H71_RS00340 63453..64370 + 918 WP_130104789.1 LysR family transcriptional regulator ArgP -
C1H71_RS00345 64525..65022 + 498 WP_130108081.1 DUF4442 domain-containing protein -
C1H71_RS00350 65077..65889 + 813 WP_130104790.1 crotonase/enoyl-CoA hydratase family protein -
C1H71_RS00355 66046..67347 - 1302 WP_130108082.1 type II toxin-antitoxin system HipA family toxin Toxin
C1H71_RS00360 67386..67682 - 297 WP_130104791.1 helix-turn-helix domain-containing protein Antitoxin
C1H71_RS00365 67909..69000 - 1092 WP_130108083.1 D-alanine--D-alanine ligase -
C1H71_RS00370 69144..70319 - 1176 WP_130104792.1 O-succinylhomoserine sulfhydrylase -
C1H71_RS00375 70485..71405 - 921 WP_130104793.1 type II secretion system minor pseudopilin GspK -
C1H71_RS00380 71402..71986 - 585 WP_188053454.1 type II secretion system minor pseudopilin GspJ -
C1H71_RS00385 72278..72649 - 372 WP_188053456.1 type II secretion system minor pseudopilin GspI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 47586.67 Da        Isoelectric Point: 8.3302

>T91955 WP_130108082.1 NZ_CP025781:c67347-66046 [Iodobacter fluviatilis]
MNGVLVGEWSRAPDGERLAYSPYWVKYRKGRPLSLSLPFTPGNQVYKGELVSAFFDNLLPDSDAIRRRLALRYQSASLAP
FDLLAVLGRDCVGAIQLLVPDESPDHLFTIKGEVLTEADIARLLRNSTVNGALGPTDLEGDLRLSIAGAQEKTALLYHKG
QWLLPEGSTPTTHIFKLPMGLVGNMQADMQTSVENEWLCAKIVAAYGLDVAACDIGRFEDQKALIVRRFDRKLSSDGRWI
IRLPQEDMCQASGTHPLRKYQIDGGPSMGQIMDILRGSSRAEQDRRDFFKAQLVFWLLAATDGHAKNFSVFQIPGGRFQS
TPLYDILSAHPIIGTGRNQLAPQKVKLAMAVRGSSNHYLLDKIQRRHWLAQARQAGLGSNVAEAIIAELLAATAEVLKSV
SAQLPTDFPPSLADAILDGVQRQCNKLAAMTAI

Download         Length: 1302 bp

>T91955 NZ_CP025781:c67347-66046 [Iodobacter fluviatilis]
ATGAATGGCGTGCTGGTGGGCGAGTGGTCCAGAGCGCCAGATGGCGAGCGCCTTGCGTATTCGCCTTATTGGGTAAAGTA
CCGCAAAGGTCGGCCTTTATCTTTGTCTTTGCCGTTTACGCCGGGTAATCAGGTTTATAAAGGCGAGCTGGTCAGCGCTT
TTTTTGACAATCTTTTACCCGATAGTGATGCCATACGCAGGCGCTTGGCATTGCGTTATCAATCAGCCAGCCTAGCACCA
TTTGATTTGCTGGCCGTGCTGGGGCGGGATTGCGTAGGGGCTATTCAGCTGCTTGTGCCTGATGAGTCCCCCGATCATTT
GTTTACGATTAAGGGCGAGGTACTTACTGAGGCCGACATTGCCCGCTTGCTTCGTAATTCAACGGTCAACGGGGCGCTGG
GGCCGACTGATTTAGAGGGTGATTTGCGGCTATCTATTGCCGGTGCTCAGGAGAAAACAGCACTGCTTTATCATAAAGGG
CAGTGGTTATTGCCCGAAGGCAGCACACCTACCACGCATATTTTTAAGCTGCCTATGGGCTTGGTCGGCAATATGCAGGC
CGATATGCAAACATCGGTGGAAAACGAATGGCTATGCGCCAAGATTGTTGCCGCTTATGGCTTGGATGTAGCGGCCTGTG
ATATTGGGCGTTTTGAGGATCAGAAAGCATTGATTGTTCGGCGCTTTGATCGAAAATTATCGAGTGATGGCCGTTGGATT
ATCCGCTTGCCGCAGGAGGATATGTGTCAGGCCAGCGGCACTCATCCTTTAAGGAAGTATCAGATTGATGGTGGCCCCAG
CATGGGGCAGATTATGGATATCTTGCGTGGATCAAGCCGCGCGGAACAAGATCGGCGTGATTTTTTTAAAGCGCAATTGG
TATTCTGGCTGCTGGCCGCAACCGATGGCCATGCCAAGAATTTTAGCGTGTTCCAAATACCCGGCGGGCGATTCCAATCC
ACGCCCCTTTACGACATCCTTTCTGCGCACCCGATTATCGGCACAGGCCGCAATCAGCTAGCACCACAAAAAGTAAAGTT
AGCCATGGCGGTGCGGGGCAGTAGCAATCATTACTTGCTGGATAAAATACAGCGTAGACACTGGTTGGCTCAGGCACGCC
AAGCAGGGCTGGGGAGTAATGTGGCAGAAGCAATCATTGCTGAGCTGCTTGCTGCTACCGCTGAAGTATTAAAGAGTGTG
AGCGCTCAATTGCCCACCGATTTTCCACCGAGCTTGGCAGATGCCATCTTGGATGGTGTGCAGCGGCAATGTAATAAGCT
CGCAGCAATGACGGCTATCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10830.27 Da        Isoelectric Point: 4.7023

>AT91955 WP_130104791.1 NZ_CP025781:c67682-67386 [Iodobacter fluviatilis]
VNYPLQTLSQLRPVLQGFRKANNLTQAALAERLGITQQTYAQLEANPASASVERLFKVLRALDVELWLSHASVTEPDVAD
AVVMAKETQLADPAQENW

Download         Length: 297 bp

>AT91955 NZ_CP025781:c67682-67386 [Iodobacter fluviatilis]
GTGAACTATCCTCTTCAAACCCTTTCTCAGTTGCGGCCTGTTTTACAGGGGTTTCGCAAGGCGAATAATCTGACGCAAGC
GGCTTTGGCGGAGCGCTTGGGGATTACTCAGCAAACTTATGCCCAGCTAGAGGCAAACCCGGCATCGGCCAGCGTAGAGC
GCTTATTTAAAGTGTTGCGTGCTTTGGATGTGGAGTTGTGGCTAAGCCACGCTTCTGTTACAGAGCCAGATGTGGCAGAT
GCCGTGGTGATGGCGAAAGAGACGCAATTGGCTGATCCCGCTCAGGAAAACTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References