Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5478550..5479189 Replicon chromosome
Accession NZ_CP025779
Organism Mycobacterium marinum strain 1218R

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A2Z5YL42
Locus tag MM1218R_RS23150 Protein ID WP_020729617.1
Coordinates 5478550..5478996 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag MM1218R_RS23155 Protein ID WP_011738542.1
Coordinates 5479001..5479189 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM1218R_RS23125 5473725..5475245 + 1521 WP_116268141.1 carotenoid oxygenase family protein -
MM1218R_RS23130 5475262..5475735 + 474 WP_012396158.1 VOC family protein -
MM1218R_RS23135 5475741..5476175 - 435 WP_012396159.1 hypothetical protein -
MM1218R_RS23140 5476246..5477019 - 774 WP_020729619.1 VOC family protein -
MM1218R_RS23145 5477188..5478438 + 1251 WP_036456440.1 hypothetical protein -
MM1218R_RS23150 5478550..5478996 - 447 WP_020729617.1 SRPBCC family protein Toxin
MM1218R_RS23155 5479001..5479189 - 189 WP_011738542.1 antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15851.39 Da        Isoelectric Point: 8.6574

>T91954 WP_020729617.1 NZ_CP025779:c5478996-5478550 [Mycobacterium marinum]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSVVSFDVHLGGPALFGPIGMVVAAALRTDINASLRNFVTVFAPSAAG

Download         Length: 447 bp

>T91954 NZ_CP025779:c5478996-5478550 [Mycobacterium marinum]
ATGGCGAAACTTTCCGGGTCGATCGACGTGCCGCTGTCTCCGGACGAGGCATGGATGCACGCATCCGATCTCTCCCGCTT
CAAGGAGTGGCTGACGATCCACCGAGTGTGGCGCAGCACGTTGCCCGAAACCCTCGAAAAGGGTGCGGTCGTCGAATCAA
TCGTGCAGGTCAAGGGCATGCACAACCGCATCAAATGGACCATCGTGCGCTACCAGCCGCCGGAAGGCATGACCCTCAAC
GGTGACGGGGTCGGCGGCGTCAAGGTCAAGCTGATGGCCAAGGTTGCAGCCGGAGAAGAAGGCTCGGTCGTCAGCTTCGA
CGTGCACCTTGGTGGGCCGGCTCTGTTCGGTCCGATCGGCATGGTCGTCGCCGCGGCGCTGCGCACCGATATCAACGCAT
CGCTGCGGAACTTCGTCACCGTATTCGCCCCGTCGGCCGCCGGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT91954 WP_011738542.1 NZ_CP025779:c5479189-5479001 [Mycobacterium marinum]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp

>AT91954 NZ_CP025779:c5479189-5479001 [Mycobacterium marinum]
ATGGGAATCCTGGACAAGGCGAAAGACCTGCTGGCGCAGAACGCCGACAAGGTCGAGACGGTGATCGACAAGGCCGGCGA
ATTCGTCGACGAGAAGACCGAGGGGAAGTACTCCGACACCATCCACAAGGTGCAAGAGGGGGCCAAGAAAGTCGCTGGTC
CCGGCGCCGCGGGCGAGCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YL42

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References