Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3468151..3468686 Replicon chromosome
Accession NZ_CP025779
Organism Mycobacterium marinum strain 1218R

Toxin (Protein)


Gene name mazF Uniprot ID A0A2Z5YH00
Locus tag MM1218R_RS14910 Protein ID WP_036455701.1
Coordinates 3468354..3468686 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7I7LGS6
Locus tag MM1218R_RS14905 Protein ID WP_036455700.1
Coordinates 3468151..3468357 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM1218R_RS14885 3463469..3464287 + 819 WP_020729182.1 ParA family protein -
MM1218R_RS14890 3464380..3465207 - 828 WP_020729183.1 DUF1906 domain-containing protein -
MM1218R_RS14895 3465535..3467220 - 1686 WP_020729184.1 GMC family oxidoreductase N-terminal domain-containing protein -
MM1218R_RS14900 3467468..3467818 - 351 WP_020729185.1 cupin domain-containing protein -
MM1218R_RS14905 3468151..3468357 + 207 WP_036455700.1 DUF3018 family protein Antitoxin
MM1218R_RS14910 3468354..3468686 + 333 WP_036455701.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MM1218R_RS14915 3469293..3469634 + 342 WP_038581564.1 DUF2384 domain-containing protein -
MM1218R_RS14920 3469635..3470189 + 555 WP_020729188.1 RES domain-containing protein -
MM1218R_RS14925 3470468..3470701 + 234 WP_020729189.1 hypothetical protein -
MM1218R_RS14930 3470691..3471002 + 312 WP_020729190.1 type II toxin-antitoxin system PemK/MazF family toxin -
MM1218R_RS14935 3471395..3471592 + 198 Protein_2918 hypothetical protein -
MM1218R_RS14940 3471765..3473099 + 1335 WP_116268308.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11841.67 Da        Isoelectric Point: 7.3196

>T91953 WP_036455701.1 NZ_CP025779:3468354-3468686 [Mycobacterium marinum]
VNRGEIWTVAGGVYATKPHPAVIVQDDLFDATSSVTVAPMSSTLLDAPLMRIRIAGGDGRLSGLDHNSDVMIDKLTTVKR
SNVHARVGRLTAEQVVEVERVMMAFLGLAR

Download         Length: 333 bp

>T91953 NZ_CP025779:3468354-3468686 [Mycobacterium marinum]
GTGAATAGAGGGGAGATCTGGACCGTAGCGGGGGGCGTCTACGCGACCAAACCGCATCCCGCGGTGATTGTTCAGGATGA
TCTCTTTGATGCCACGAGTTCGGTGACGGTTGCTCCGATGTCCAGCACCCTGTTGGATGCGCCGTTGATGCGCATCCGAA
TAGCCGGCGGAGACGGCCGGTTATCCGGACTTGATCACAACAGTGACGTGATGATCGACAAGCTCACAACCGTGAAAAGG
TCGAACGTCCATGCCCGAGTCGGTCGGCTGACAGCGGAGCAAGTCGTCGAGGTCGAGCGAGTGATGATGGCATTCCTCGG
CCTTGCGCGATAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7999.86 Da        Isoelectric Point: 4.8359

>AT91953 WP_036455700.1 NZ_CP025779:3468151-3468357 [Mycobacterium marinum]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARADERGDDQDFIEAISTPWDEE

Download         Length: 207 bp

>AT91953 NZ_CP025779:3468151-3468357 [Mycobacterium marinum]
ATGGCGGTTAGGGACAGGGTCGGCGAGTACCGACGGCGGATGCGGGAGCGGGGCCTGCGGCCGCTGCAGGTCTGGGTGCC
TGACGTGCGCACTGAGAGTTTTGCTGCCGAGGCGCATCGTCAGGCTTCGTTGGTCGCACGAGCGGACGAACGCGGCGATG
ATCAGGACTTCATTGAGGCCATCTCGACGCCATGGGATGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YH00

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LGS6

References