Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4933209..4933863 Replicon chromosome
Accession NZ_CP025757
Organism Citrobacter freundii complex sp. CFNIH2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag WM46_RS24250 Protein ID WP_102603583.1
Coordinates 4933456..4933863 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag WM46_RS24245 Protein ID WP_102603582.1
Coordinates 4933209..4933475 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM46_RS24220 4928422..4929855 - 1434 WP_102603578.1 6-phospho-beta-glucosidase BglA -
WM46_RS24225 4929976..4930704 - 729 WP_102603579.1 MurR/RpiR family transcriptional regulator -
WM46_RS24230 4930757..4931068 + 312 WP_102603580.1 N(4)-acetylcytidine aminohydrolase -
WM46_RS24235 4931231..4931890 + 660 WP_061075276.1 hemolysin III family protein -
WM46_RS24240 4931972..4932952 - 981 WP_102603581.1 tRNA-modifying protein YgfZ -
WM46_RS24245 4933209..4933475 + 267 WP_102603582.1 FAD assembly factor SdhE Antitoxin
WM46_RS24250 4933456..4933863 + 408 WP_102603583.1 protein YgfX Toxin
WM46_RS24255 4933964..4934485 - 522 WP_102603584.1 flavodoxin FldB -
WM46_RS24260 4934586..4935482 + 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
WM46_RS24265 4935506..4936219 + 714 WP_061075272.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
WM46_RS24270 4936225..4937958 + 1734 WP_061075271.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15917.85 Da        Isoelectric Point: 11.3523

>T91952 WP_102603583.1 NZ_CP025757:4933456-4933863 [Citrobacter freundii complex sp. CFNIH2]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVNAPWMIKTGMMLRLRSETGKRQHLWLAADSMDDAEWRDLRRLMIQQSKQG

Download         Length: 408 bp

>T91952 NZ_CP025757:4933456-4933863 [Citrobacter freundii complex sp. CFNIH2]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTACTCCTGCATGGGCTGGTGGCCGC
GGCTATTCTATTAATGCCATGGCCGCTGAGTTATACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTGTTTGACTGTG
TCCGCAGCCAGCGACGAATTAACGCCCGTCAGGGGGAGGTCAAACTTCTGATGGATGGACGGCTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAATGCACCGTGGATGATCAAAACTGGCATGATGCTGCGTCTGCGTTCAGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATGACGCGGAATGGCGGGATTTACGCCGCCTGATGATTCAACAGTCGAAGC
AAGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.09 Da        Isoelectric Point: 4.8667

>AT91952 WP_102603582.1 NZ_CP025757:4933209-4933475 [Citrobacter freundii complex sp. CFNIH2]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT91952 NZ_CP025757:4933209-4933475 [Citrobacter freundii complex sp. CFNIH2]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAATATGAATACGACACGTTGAGTGATGATGAAAAGCGTATTTTTATCCGCCTGCTGGAGTGCGATGACCCGGACT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References