Detailed information of TA system TA091951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4735587..4736103
• Replicon: chromosome
• Accession: NZ_CP025757
• Organism: Citrobacter freundii complex sp. CFNIH2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: WM46_RS23250
• Protein ID: WP_102603472.1
• Coordinates: 4735819..4736103 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: WM46_RS23245
• Protein ID: WP_102603471.1
• Coordinates: 4735587..4735829 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM46_RS23225	4730609..4731742	+	1134	WP_102603468.1	amidohydrolase/deacetylase family metallohydrolase	-
WM46_RS23230	4731726..4732844	+	1119	WP_102603469.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
WM46_RS23235	4732841..4733581	+	741	WP_102603470.1	KDGP aldolase family protein	-
WM46_RS23240	4733598..4735508	+	1911	WP_061075406.1	BglG family transcription antiterminator	-
WM46_RS23245	4735587..4735829	+	243	WP_102603471.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
WM46_RS23250	4735819..4736103	+	285	WP_102603472.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WM46_RS23255	4736112..4736576	-	465	WP_061075405.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
WM46_RS23260	4736749..4738887	-	2139	WP_102603473.1	anaerobic ribonucleoside-triphosphate reductase	-
WM46_RS23270	4739297..4740952	-	1656	WP_102603475.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10960.84 Da
• Isoelectric Point: 10.2499

>T91951 WP_102603472.1 NZ_CP025757:4735819-4736103 [Citrobacter freundii complex sp. CFNIH2]
MSYELEFDPRALKEWQKLGETVKNQFRKKLAEVLSHPRIPSARLHDFPDCYKIKLKASGFRLVYQVKDAQVLVLVIAIGK
REKSAVYQDADKRL

Nucleotide

• Length: 285 bp

>T91951 NZ_CP025757:4735819-4736103 [Citrobacter freundii complex sp. CFNIH2]
ATGAGCTATGAACTGGAGTTTGATCCGCGGGCGCTGAAGGAATGGCAAAAATTGGGTGAAACAGTGAAAAATCAGTTCAG
GAAGAAACTGGCTGAGGTGCTTTCACATCCGCGGATCCCCTCCGCGCGGCTTCATGACTTTCCTGATTGCTACAAGATAA
AACTCAAGGCGTCTGGCTTCAGGCTGGTCTATCAGGTGAAGGACGCACAGGTTCTGGTACTGGTGATCGCTATTGGTAAA
CGGGAAAAATCGGCCGTTTATCAGGACGCTGACAAACGGCTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9040.45 Da
• Isoelectric Point: 5.0807

>AT91951 WP_102603471.1 NZ_CP025757:4735587-4735829 [Citrobacter freundii complex sp. CFNIH2]
MATLNVRLDDKLKNEAYAVLDKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEEALLQTVRERLANPQKGIKVQLDEL

Nucleotide

• Length: 243 bp

>AT91951 NZ_CP025757:4735587-4735829 [Citrobacter freundii complex sp. CFNIH2]
ATGGCCACATTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCGTACGCCGTGCTGGATAAACTCAATATTACGCC
TACGGAAGCCGTAAGACTGCTTTTTCAGTACGTGGCTGAAAATGGACGAATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGAGGCGCTACTTCAGACCGTCCGGGAACGACTGGCTAACCCGCAAAAGGGCATTAAGGTTCAGTTGGATGAGCTA
TGA