Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4546441..4547198 Replicon chromosome
Accession NZ_CP025757
Organism Citrobacter freundii complex sp. CFNIH2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag WM46_RS22215 Protein ID WP_102603352.1
Coordinates 4546716..4547198 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag WM46_RS22210 Protein ID WP_102603351.1
Coordinates 4546441..4546725 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM46_RS22185 4542681..4543502 + 822 Protein_4203 ParB family protein -
WM46_RS22190 4543483..4544295 + 813 Protein_4204 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
WM46_RS22195 4544921..4545418 + 498 WP_102603876.1 DUF3577 domain-containing protein -
WM46_RS22200 4545492..4545695 + 204 WP_102603349.1 hypothetical protein -
WM46_RS22205 4545713..4546261 + 549 WP_102603350.1 single-stranded DNA-binding protein -
WM46_RS22210 4546441..4546725 + 285 WP_102603351.1 DUF1778 domain-containing protein Antitoxin
WM46_RS22215 4546716..4547198 + 483 WP_102603352.1 GNAT family N-acetyltransferase Toxin
WM46_RS22220 4547479..4548287 + 809 Protein_4210 TcpQ domain-containing protein -
WM46_RS22225 4548289..4548726 + 438 WP_102603353.1 type IV pilus biogenesis protein PilM -
WM46_RS22230 4548738..4550408 + 1671 WP_102603354.1 PilN family type IVB pilus formation outer membrane protein -
WM46_RS22235 4550405..4551706 + 1302 WP_102603355.1 type 4b pilus protein PilO2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-146)

Antitoxin

Vibrio phage ICP1, Orf50

(2-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17878.65 Da        Isoelectric Point: 6.9569

>T91950 WP_102603352.1 NZ_CP025757:4546716-4547198 [Citrobacter freundii complex sp. CFNIH2]
MEINVTAPVLLTEQHVLEPFDCGNEVLDDWLRRRAMKNQHLNASRTFVICLEGTMRVVGYYSIATGSVSHVDLGRSLRQN
MPDPIPVVLLGRLAVDVCTQGHNYGKWLLNDAVVRVSSLADQVGIKAIMVHAINEQAKAFYEYFGFVQSPVAANTLFYKI

Download         Length: 483 bp

>T91950 NZ_CP025757:4546716-4547198 [Citrobacter freundii complex sp. CFNIH2]
ATGGAAATAAATGTCACTGCGCCTGTTTTACTGACAGAACAGCATGTTCTTGAGCCGTTCGATTGCGGGAATGAGGTACT
TGATGACTGGCTTCGTCGGCGTGCGATGAAGAATCAGCATCTCAATGCTTCCCGCACATTCGTCATTTGCCTGGAAGGTA
CCATGCGTGTAGTAGGGTATTATTCCATCGCGACTGGCTCAGTGAGTCATGTCGATTTGGGGCGTAGCCTGCGGCAGAAT
ATGCCAGATCCAATACCGGTTGTTTTGCTGGGCCGCCTTGCAGTCGATGTATGTACTCAGGGACATAACTACGGAAAATG
GTTGCTGAATGACGCAGTGGTACGCGTCTCGAGTCTGGCAGACCAGGTCGGAATCAAGGCTATCATGGTGCATGCAATTA
ATGAGCAGGCTAAAGCGTTCTATGAATATTTTGGCTTTGTGCAGTCACCAGTTGCGGCCAACACGTTATTCTACAAAATA
TGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11040.58 Da        Isoelectric Point: 7.0159

>AT91950 WP_102603351.1 NZ_CP025757:4546441-4546725 [Citrobacter freundii complex sp. CFNIH2]
MQTTIRKSVRDKQINIRATDEERAVIDYAAGLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQEFIKQLEAPVQNV
EGRQRLMDAKPEWK

Download         Length: 285 bp

>AT91950 NZ_CP025757:4546441-4546725 [Citrobacter freundii complex sp. CFNIH2]
ATGCAAACTACTATCCGTAAATCTGTTCGTGATAAGCAAATAAATATCCGGGCAACTGATGAGGAACGTGCAGTGATTGA
TTATGCTGCAGGTCTGGTTAACAAAAATCGTACTGATTTCATCATTGAGAAGGCTGTGCACGAGGCCCAAAATATAATCC
TGGATCAGCGCGTGTTCGTCCTGGATGATGCCCGTTACCAGGAATTCATTAAGCAGCTGGAAGCACCTGTGCAGAATGTT
GAAGGTCGTCAGCGGCTGATGGATGCAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References