Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4381493..4382081 Replicon chromosome
Accession NZ_CP025757
Organism Citrobacter freundii complex sp. CFNIH2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag WM46_RS21385 Protein ID WP_102603869.1
Coordinates 4381764..4382081 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag WM46_RS21380 Protein ID WP_102603261.1
Coordinates 4381493..4381771 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM46_RS21365 4378308..4378709 + 402 WP_187394410.1 hypothetical protein -
WM46_RS21370 4378977..4380608 + 1632 WP_102603259.1 Na/Pi cotransporter family protein -
WM46_RS21375 4380693..4381382 - 690 WP_102603260.1 dipeptidase PepE -
WM46_RS21380 4381493..4381771 - 279 WP_102603261.1 putative addiction module antidote protein Antitoxin
WM46_RS21385 4381764..4382081 - 318 WP_102603869.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM46_RS26430 4382156..4382371 - 216 WP_187394518.1 hypothetical protein -
WM46_RS21390 4382296..4382589 + 294 WP_102603262.1 type II toxin-antitoxin system CcdA family antitoxin -
WM46_RS21395 4382644..4383456 - 813 WP_102603263.1 shikimate 5-dehydrogenase -
WM46_RS21400 4383458..4384678 - 1221 WP_102603264.1 L-sorbose 1-phosphate reductase -
WM46_RS21405 4384732..4385556 - 825 WP_046493831.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
WM46_RS21410 4385568..4386365 - 798 WP_102603265.1 PTS mannose/fructose/sorbose transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(1-90)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11768.51 Da        Isoelectric Point: 9.6257

>T91949 WP_102603869.1 NZ_CP025757:c4382081-4381764 [Citrobacter freundii complex sp. CFNIH2]
IVEILQTAVFQRWEQSLRDRRAKTLIASRLFRLANGLPGDVKPVGEGISELRIHHGPGYRIYFRQQGNVIIVLLCGGDKS
SQTKDIVLAKAIANSLDYQELANHD

Download         Length: 318 bp

>T91949 NZ_CP025757:c4382081-4381764 [Citrobacter freundii complex sp. CFNIH2]
ATCGTGGAAATACTTCAAACGGCGGTCTTTCAGCGCTGGGAACAAAGTCTGAGGGATCGCAGAGCAAAAACACTCATTGC
TTCGCGTCTGTTTCGTCTGGCAAATGGATTACCAGGCGATGTTAAACCCGTTGGCGAAGGTATCAGCGAATTGCGTATCC
ACCATGGACCCGGTTACCGGATTTACTTCAGGCAGCAAGGAAATGTCATCATCGTTTTGCTCTGTGGTGGCGATAAAAGC
TCGCAAACAAAAGATATTGTTCTCGCCAAAGCCATTGCCAATTCACTGGATTATCAGGAGCTCGCCAACCATGACTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9865.47 Da        Isoelectric Point: 7.0098

>AT91949 WP_102603261.1 NZ_CP025757:c4381771-4381493 [Citrobacter freundii complex sp. CFNIH2]
MTKLTHYDPAAALVDDEEMTVFMAEALETGDATYIAKALGVVARAKGMVNIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGISLTVKK

Download         Length: 279 bp

>AT91949 NZ_CP025757:c4381771-4381493 [Citrobacter freundii complex sp. CFNIH2]
ATGACTAAGCTTACGCACTACGATCCCGCCGCTGCATTGGTTGATGACGAAGAGATGACCGTGTTTATGGCGGAGGCCCT
GGAAACCGGTGACGCGACTTATATCGCAAAGGCGTTAGGCGTCGTGGCCCGTGCAAAAGGGATGGTGAATATTGCGGCGG
AAACGGGTTTATCACGCGAGCAGCTTTATCGTTCATTCAGCGAGAAAGGCAACCCGACGCTGAAAACCACGCTGGCAGTG
ATGAAGGCGCTGGGAATCAGCCTCACCGTTAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References