Detailed information of TA system TA091945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1900138..1900957
• Replicon: chromosome
• Accession: NZ_CP025757
• Organism: Citrobacter freundii complex sp. CFNIH2

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A2K9PA99
• Locus tag: WM46_RS09465
• Protein ID: WP_061077081.1
• Coordinates: 1900700..1900957 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: WM46_RS09460
• Protein ID: WP_102602106.1
• Coordinates: 1900138..1900689 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM46_RS09435	1895254..1895727	+	474	WP_102602101.1	PTS sugar transporter subunit IIA	-
WM46_RS09440	1895749..1897155	+	1407	WP_102602102.1	fructose-specific PTS transporter subunit EIIC	-
WM46_RS09445	1897158..1898018	+	861	WP_102602103.1	ketose-bisphosphate aldolase	-
WM46_RS09450	1898078..1898662	-	585	WP_102602104.1	hypothetical protein	-
WM46_RS09455	1899340..1900086	-	747	WP_102602105.1	class I SAM-dependent methyltransferase	-
WM46_RS09460	1900138..1900689	-	552	WP_102602106.1	N-acetyltransferase	Antitoxin
WM46_RS09465	1900700..1900957	-	258	WP_061077081.1	YjhX family toxin	Toxin
WM46_RS09475	1901409..1901972	+	564	WP_187394474.1	DUF2975 domain-containing protein	-
WM46_RS09480	1901986..1902210	+	225	WP_102602108.1	helix-turn-helix transcriptional regulator	-
WM46_RS09485	1902393..1903823	+	1431	WP_102602109.1	aspartyl protease family protein	-
WM46_RS09490	1903870..1904673	-	804	WP_102602110.1	tryptophan synthase subunit alpha	-
WM46_RS09495	1904673..1905866	-	1194	WP_102602111.1	tryptophan synthase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.05 Da
• Isoelectric Point: 11.1381

>T91945 WP_061077081.1 NZ_CP025757:c1900957-1900700 [Citrobacter freundii complex sp. CFNIH2]
MNLSRQEQRTLHVLAKGGRITHVRDASGRVTAVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T91945 NZ_CP025757:c1900957-1900700 [Citrobacter freundii complex sp. CFNIH2]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGACGTATTACGCACGTCCGCGATGCGTC
AGGCCGCGTCACTGCCGTTGAATGCTACAGCCGCGAAGGGTTGCTGCTCACCGACTGTACACTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAGCTGATCAAATCCGTTAATGGTCAGCCGTACCGCATTAATACCACCGGGCTGAACAACGTTCGTGCT
CAGCCAGATAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20337.28 Da
• Isoelectric Point: 6.2852

>AT91945 WP_102602106.1 NZ_CP025757:c1900689-1900138 [Citrobacter freundii complex sp. CFNIH2]
MTTRNFTFHITDESDANDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQEGTAVGHILFTRATFKGEMNSPLMH
ILAPLAVIPEYQGKGVGGLLIRTGLEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGYPAPYPIAEEHKACWMMQSLSA
QPLDRVGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT91945 NZ_CP025757:c1900689-1900138 [Citrobacter freundii complex sp. CFNIH2]
ATGACAACACGCAACTTCACTTTTCATATCACCGATGAAAGTGATGCCAACGACATCCGGGAAGTCGAAACCCGCGCCTT
TGGCTACAGTAAAGAGGCCTGCCTGGTGGCTTCTTTGCTCGAGGACGACACCGCGCGCCCAACGTTATCGTTGCTGGCCA
GGCAGGAAGGTACAGCCGTCGGACATATCCTGTTTACCCGGGCGACCTTTAAAGGAGAAATGAATTCGCCGCTGATGCAT
ATCCTGGCTCCTCTGGCGGTCATACCTGAATACCAGGGGAAGGGCGTGGGCGGATTATTGATTCGTACCGGTTTAGAACA
CTTACGGTCGATGGGATGTCAGTGCGTTTTTGTTCTCGGTCATGCCACTTACTATCCGCGACATGGATTCGAACCCTGCG
CAGGAGACAAAGGCTATCCCGCGCCTTACCCCATTGCGGAGGAACATAAGGCCTGCTGGATGATGCAGTCCCTCTCTGCA
CAACCCCTTGATCGTGTCGGCGACATTCAATGTGCGCAGGCCTTAATGAAACCGGAGCACTGGCGTGAATAG

Structures

Toxin

• AlphaFold DB: A0A2K9PA99