Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 896922..897451 Replicon chromosome
Accession NZ_CP025754
Organism Enterococcus faecium strain AALTL

Toxin (Protein)


Gene name relE Uniprot ID A0A828ZPW6
Locus tag BXT96_RS04625 Protein ID WP_002301121.1
Coordinates 896922..897188 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag BXT96_RS04630 Protein ID WP_002294199.1
Coordinates 897188..897451 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BXT96_RS04600 892289..893464 + 1176 WP_002348889.1 betaine/proline/choline family ABC transporter ATP-binding protein -
BXT96_RS04605 893468..894109 + 642 WP_002293405.1 ABC transporter permease -
BXT96_RS04610 894106..895023 + 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
BXT96_RS04615 895020..895691 + 672 WP_002301116.1 ABC transporter permease -
BXT96_RS16185 895887..896721 - 835 Protein_833 hypothetical protein -
BXT96_RS04625 896922..897188 - 267 WP_002301121.1 Txe/YoeB family addiction module toxin Toxin
BXT96_RS04630 897188..897451 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BXT96_RS04640 897926..898111 + 186 WP_002348885.1 hypothetical protein -
BXT96_RS04645 898253..900076 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 880321..906125 25804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10619.04 Da        Isoelectric Point: 9.8346

>T91932 WP_002301121.1 NZ_CP025754:c897188-896922 [Enterococcus faecium]
MSNYTVAIKNSATVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T91932 NZ_CP025754:c897188-896922 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGACAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAGAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT91932 WP_002294199.1 NZ_CP025754:c897451-897188 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT91932 NZ_CP025754:c897451-897188 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZPW6

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References