Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4496619..4497145 | Replicon | chromosome |
| Accession | NZ_CP025753 | ||
| Organism | Escherichia coli strain CV839-06 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | CV83906_RS24130 | Protein ID | WP_000323025.1 |
| Coordinates | 4496619..4496906 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | CV83906_RS24135 | Protein ID | WP_000534858.1 |
| Coordinates | 4496906..4497145 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CV83906_RS24090 | 4491643..4491858 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| CV83906_RS27040 | 4492078..4492248 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| CV83906_RS24095 | 4492612..4492827 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| CV83906_RS24100 | 4493128..4493340 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| CV83906_RS26730 | 4493395..4493484 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| CV83906_RS24105 | 4493762..4494514 | - | 753 | WP_001047135.1 | antitermination protein | - |
| CV83906_RS24110 | 4494528..4495577 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| CV83906_RS24115 | 4495579..4495857 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| CV83906_RS24120 | 4495924..4496175 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| CV83906_RS24125 | 4496392..4496547 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| CV83906_RS24130 | 4496619..4496906 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| CV83906_RS24135 | 4496906..4497145 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| CV83906_RS24140 | 4497170..4497475 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| CV83906_RS24145 | 4497678..4498010 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| CV83906_RS24155 | 4498447..4499787 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| CV83906_RS24160 | 4499821..4500240 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| CV83906_RS24165 | 4500281..4501246 | - | 966 | WP_000054506.1 | hypothetical protein | - |
| CV83906_RS24170 | 4501227..4501748 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| CV83906_RS24175 | 4501732..4501959 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4461236..4514284 | 53048 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T91922 WP_000323025.1 NZ_CP025753:c4496906-4496619 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T91922 NZ_CP025753:c4496906-4496619 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT91922 WP_000534858.1 NZ_CP025753:c4497145-4496906 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT91922 NZ_CP025753:c4497145-4496906 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|